Evidence map›Paper›PMID 32809170›Full record

ArticleJournal of autism and developmental disorders2021

Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome.

Siddharth Srivastava, Bennett Clark, Colleen Landy-Schmitt, Elizabeth A Offermann, Antonie D Kline, Samuel T Wilkinson, Marco A Grados

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Siddharth SrivastavaDepartment of Neurology, Boston Children's Hospital, Boston, MA, USA.
Bennett ClarkDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Colleen Landy-SchmittMyriad Women's Health, Salt Lake City, UT, USA.
Elizabeth A OffermannKennedy Krieger Institute, Baltimore, MD, USA.
Antonie D KlineHarvey Institute for Human Genetics, Greater Baltimore Medical Center, Baltimore, MD, USA.
Samuel T WilkinsonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Marco A GradosDepartment of Psychiatry, The Johns Hopkins Hospital, Bloomberg Children's Center, Johns Hopkins University School of Medicine, 12th Floor, 1800 Orleans Street, Baltimore, MD, 21287, USA. mjgrados@jhmi.edu.
Boston Children's Hospital · USGreater Baltimore Medical Center · USJohns Hopkins University · USKennedy Krieger Institute · USMyriad Genetics · USUniversity of Minnesota · USYale University · US

Funding

NIH HHS 5K12HS023000
6 · The paper itself

Abstract

Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children (5-17 years) with CdLS were assessed with Children's Yale-Brown Obsessive Compulsive Scale Modified for PDD; Aberrant Behavior Checklist (ABC); Vineland Adaptive Behaviors Scales (VABS). All children had ≥ 1 type of RB; 44% had some form of SIB. 64% spent > 1 h/day displaying RBs. Lower VABS adaptive functioning was associated with higher stereotypy and SIB scores (ABC). In children with CdLS, RBs including SIB are common, impactful, and associated with lower adaptive functioning.

Indexed as

Stereotyped BehaviorAdolescentChildChild, PreschoolCohort StudiesDe Lange SyndromeFemaleHumansMaleSelf-Injurious BehaviorCornelia de Lange syndromeRepetitive behaviorsSelf-injurious behaviorsStereotypies

Identifiers

PMID32809170
OpenAlexW3055612126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.