Evidence map›Paper›PMID 32809151›Full record

ArticleJournal of neurology2021

The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.

Marina Picillo, Raffaele Palladino, Roberto Erro, Rossella Alfano, Carlo Colosimo, Roberto Marconi, Angelo Antonini, Paolo Barone, PRIAMO study group

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Article
  5. Gut neuropeptide involvement in Parkinson's disease.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  6. Article
  7. Review
  8. Constipation and pain in Parkinson's disease: a clinical analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Article
  9. Article
  10. Review
  11. Spotlight on non-motor symptoms and Covid-19.International review of neurobiology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Marina PicilloDepartment of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy.ORCID http://orcid.org/0000-0001-9025-137X
Raffaele PalladinoDepartment of Primary Care and Public Health, School of Public Health, Imperial College of London, London, UK.
Roberto ErroDepartment of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy.
Rossella AlfanoDepartment of Public Health, School of Medicine, University "Federico II", Naples, Italy.
Carlo ColosimoDepartment of Neurology, Santa Maria University Hospital, Terni, Italy.
Roberto MarconiNeurology Division, Misericordia Hospital, Grosseto, Italy.
Angelo AntoniniDepartment of Neurosciences (DNS), Padova University, Padua, Italy.
Paolo BaroneDepartment of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy. pbarone@unisa.it.
PRIAMO study group
University of Padua · ITOspedale Misericordia - Grosseto · ITFederico II University Hospital · ITSanta Maria Nuova Hospital · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.

methodsA total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).

resultsAs for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.

conclusionsProdromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype.

Indexed as

ApathyParkinson DiseaseAgedBiomarkersConstipationFemaleHumansMalePhenotypeProdromal SymptomsBiomarkersConstipationHeterogeneityParkinsonPhenotypeProdromalSex

Identifiers

PMID32809151
PMCPMC7880965
OpenAlexW3069883839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.