ArticleJournal of cancer research and clinical oncology2021
Rational surgical neck management in total laryngectomy for advanced stage laryngeal squamous cell carcinomas.
Article in Journal of cancer research and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Is Level IIB Dissection Necessary in the Clinically N0 Neck? A Systematic Review and Meta-Analysis in Head and Neck Squamous Cell Carcinoma.Head & neck · 2026Pooled it
- Defining a minimum nodal yield for neck dissection in mucosal head and neck squamous cell carcinoma, a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Guidelines for the Treatment of Laryngeal Cancer from the Korean Society of Head and Neck Surgery.Clinical and experimental otorhinolaryngology · 2025Guideline
- Selective neck dissection of level IIB in cN0 laryngeal cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- [Neck dissection-more, less, targeted?]HNO · 2026Review
- Factors associated with occult ipsilateral and contralateral nodal metastasis in resectable lateralized laryngeal and hypopharyngeal malignancies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Prognostic impact of lymph node count features in total laryngectomy for advanced laryngeal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2025Article
- Safety of Primary Tracheoesophageal Puncture in Patients Submitted to Enlarged Total Laryngectomy with Pectoralis Major Reconstruction.Journal of personalized medicine · 2025Article
- Total Laryngectomy: A Review of Surgical Techniques.Cureus · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeControversies exist in regard to surgical neck management in total laryngectomies (TL). International guidelines do not sufficiently discriminate neck sides and sublevels, or minimal neck-dissection nodal yield (NY).
methodsThirty-seven consecutive primary TL cases from 2009 to 2019 were retrospectively analyzed in terms of local tumor growth using a previously established imaging scheme, metastatic neck involvement, and NY impact on survival.
resultsThere was no case of level IIB involvement on any side. For type A and B tumor midline involvement, no positive contralateral lymph nodes were found. Craniocaudal tumor extension correlated with contralateral neck involvement (OR: 1.098, p = 0.0493) and showed increased involvement when extending 33 mm (p = 0.0134). Using a bilateral NY of ≥ 24 for 5-year overall survival (OS) and ≥ 26 for 5-year disease-free survival (DFS) gave significantly increased rate advantages of 64 and 56%, respectively (both p < 0.0001).
conclusionsThis work sheds light on regional metastatic distribution pattern and its influence on TL cases. An NY of n ≥ 26 can be considered a desirable benchmark for bilateral selective neck dissections as it leads to improved OS and DFS. Therefore, an omission of distinct neck levels cannot be promoted at this time.
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