ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522387 (An Open Label Extension of XPro1595 in Patients With Alzheimer's Disease That Have Completed a Phase 1 or Phase 2 Study With XPro1595), which is not on this map. Cited by 42 papers.
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42citing papers in PubMed
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open Label Extension of XPro1595 in Patients With Alzheimer's Disease That Have Completed a Phase 1 or Phase 2 Study With XPro1595
Who cites it
42 citing papers in PubMed, 54 citations in OpenAlex.
- Functional Connectome Predicts Cognition and Links White Matter Hyperintensity Burden to Cognitive Impairment Across the Vascular Cognitive Impairment Continuum.Brain sciences · 2026Article
- Diabetes, hyperglycemia, and brain MRI biomarkers: results from SOL-INCA MRI study.Nutrition & diabetes · 2026Article
- Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies.medRxiv : the preprint server for health sciences · 2026Article
- Evaluating regional and global diffusion measures as biomarkers for vascular contributions to cognitive impairment and dementia.Cerebral circulation - cognition and behavior · 2026Article
- Altered glymphatic function in nasopharyngeal carcinoma following radiotherapy: novel insights from choroid plexus volume and free-water fraction analyses.Frontiers in neuroscience · 2026Article
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Mapping the Association of Cerebral Small Vessel Disease, Gray Matter Integrity, and Cognitive Function.Neurology · 2025Article
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Spatial-temporal interactions between white matter hyperintensities and multiple pathologies across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Epigenetic age acceleration predicts subject-specific white matter degeneration in the human brain.Aging cell · 2025Article
- White matter injuries mediate brain age effects on cognitive function in cerebral small vessel disease.Neuroradiology · 2025Article
- Free Water as a Marker of Early Small Vessel Disease in Healthy Aging.European journal of neurology · 2025Article
- The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study.Cerebral circulation - cognition and behavior · 2025Article
- Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Heart-brain mapping: Cardiac atrial function is associated with distinct cerebral regions with high free water in older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Diffusion tensor imaging in cerebral small vessel disease applications: opportunities and challenges.Frontiers in neuroscience · 2024Review
- Microstructural white matter integrity in relation to vascular reactivity in Dutch-type hereditary cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Spatial-temporal patterns of brain disconnectome in Alzheimer's disease.Human brain mapping · 2023Article
- Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline: A Diffusion-MRI Study.Neurology · 2023Article
Corrections and comments
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Authors and funding
53 authors at 16 institutions in 7 countries.
Sofia FinsterwalderInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Naomi VlegelsDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Benno GesierichInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Miguel Á Araque CaballeroInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Nick A WeaverDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Nicolai FranzmeierInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Marios K GeorgakisInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Marek J KoniecznyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Huiberdina L KoekDepartment of Geriatrics, University Medical Center Utrecht, Utrecht, the Netherlands.
Dominantly Inherited Alzheimer Network (DIAN)
Celeste M KarchDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Stephen SallowayButler Hospital, Providence, Rhode Island, USA.
Hwamee OhDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Ricardo F AllegriDepartment of Cognitive Neurology, FLENI Institute for Neurological Research, Buenos Aires, Argentina.
Jasmeer P ChhatwalMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
DELCODE study group
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Laura DobischGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Coraline MetzgerGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Enise I IncesoyCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany.
Josef PrillerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Eike J SpruthGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Anja SchneiderGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Klaus FließbachGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Katharina BuergerInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Daniel JanowitzInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Stefan J TeipelGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Ingo KilimannGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Christoph LaskeGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Martina BuchmannGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Michael T HenekaGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Frederic BrosseronGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Annika SpottkeGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Nina RoyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Birgit Ertl-WagnerInstitute of Clinical Radiology, University Hospital, LMU Munich, Munich, Germany.
Klaus SchefflerDepartment for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
Utrecht VCI study group
Sang Won SeoDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yeshin KimDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Duk L NaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Hee Jin KimDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Hyemin JangDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Michael EwersInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Johannes LevinGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Reinhold SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
Ofer PasternakDepartment of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Martin DichgansInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Geert Jan BiesselsDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Marco DueringInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
German Center for Neurodegenerative Diseases · DELMU Klinikum · DEUniversity Hospital Bonn · DEUtrecht University · NLSamsung Medical Center · KRBrigham and Women's Hospital · USHarvard University · USMedical University of Graz · ATProvidence College · USUniversity of Bonn · DEWashington University in St. Louis · USBrown University · USKangwon National University · KRSamsung (South Korea) · KRUniversity of California, San Francisco · USUniversity of Cologne · DE
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MAustrian Science Fund FWF I 2889NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG032438
Abstract
introductionMicrostructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.
methodsWe studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.
resultsSVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant. DISCUSSION: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
Indexed as
AdultAgedAlzheimer DiseaseBrainCerebral Small Vessel DiseasesDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedAlzheimer's diseasebiomarkercerebral small vessel diseasediffusion tensor imagingfree water imagingwhite matter
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Registered trials
NCT05522387ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.