Evidence map›Paper›PMID 32808654›Full record

ArticleBioscience reports2020

Association between ALMS 1 variants and early-onset coronary artery disease: a case-control study in Chinese population.

Shao-Yan Zhang, Chao Xuan, Yi Wang, Shao-Qiang Zhang, Hui Li, Guo-Wei He, Qing-Wu Tian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shao-Yan ZhangDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Chao XuanDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yi WangDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Shao-Qiang ZhangDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao, China.
Hui LiDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Guo-Wei HeDepartment of Surgery, TEDA International Cardiovascular Hospital, Tianjin and The Affiliated Hospital of Hangzhou Normal University and Zhejiang University, Hangzhou, China.
Qing-Wu TianDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Qingdao University · CNOregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenome-wide linkage analysis revealed the polymorphism of rs6748040 and glutamic acid repeat are potential pathogenic factors of early-onset myocardial infarction (MI). The present study was designed to investigate the associations of Alström syndrome 1 (ALMS 1) gene in Chinese populations with early-onset coronary artery disease (CAD).

methodsThe two variants of the ALMS 1 gene were genotyped in 1252 early-onset CAD patients and 1378 controls using PCR, followed by Sml I restriction enzyme digestion or direct sequencing of the PCR product. The associations were estimated using the odds ratio (OR) and the 95% confidence interval (CI).

resultsA significant association between the ALMS 1 G/A variant and the risk of early-onset MI was detected in G vs.A (OR = 1.371, 95% CI: 1.183-1.589), GG vs. AA (OR = 2.037, 95% CI: 1.408-2.948), dominant genetic model (OR = 1.794, 95% CI: 1.254-2.567), and recessive genetic model (OR = 1.421, 95% CI: 1.177-1.716). 14 glutamic acid repeat (A14) is risk factor for early-onset MI (OR = 1.605, 95% CI: 1.313-1.962) and 17 glutamic acid repeat (A17) is protective factor for the disease (OR = 0.684, 95% CI: 0.601-0.827). These associations were not detected in early-onset CAD patients.

conclusionsOur findings indicated that G/A variant (rs6748040) and glutamic acid repeat polymorphism of the ALMS 1 gene associated with the risk of early-onset MI in the Chinese population.

Indexed as

AdultAge of OnsetAsian PeopleCase-Control StudiesCell Cycle ProteinsCoronary Artery DiseaseExonsFemaleGene FrequencyGenetic Predisposition to DiseaseHumansIntronsMaleMiddle AgedPolymorphism, Single NucleotideALMS1 protein, humanCell Cycle ProteinsALMS 1Coronary Artery DiseaseGlutamic Acid RepeatMyocardial Infarction

Identifiers

PMID32808654
PMCPMC7463302
OpenAlexW3078896990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.