Evidence map›Paper›PMID 32808593›Full record

ArticleeLife2020

Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress.

Suneeta Chimalapati, Marcela de Souza Santos, Alexander E Lafrance, Ann Ray, Wan-Ru Lee, Giomar Rivera-Cancel, Gonçalo Vale, Krzysztof Pawlowski, Matthew A Mitsche, Jeffrey G McDonald and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Protective Role ofMicroorganisms · 2025
    Article
  4. A critical role forProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microbial genomics · 2023
    Article
  11. Review
  12. Adaptations ofFrontiers in microbiology · 2021
    Review
  13. VscF in T3SS1 Helps to Translocate VPA0226 inFrontiers in cellular and infection microbiology · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Suneeta Chimalapati *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Marcela de Souza Santos *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Alexander E LafranceDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Ann RayDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-5803-2919
Wan-Ru LeeDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.
Giomar Rivera-CancelDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-4909-4103
Gonçalo ValeCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, United States.
Krzysztof PawlowskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Matthew A MitscheCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, United States.
Jeffrey G McDonaldCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, United States.
Jen LiouDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0003-1546-3115
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-0678-7620
The University of Texas Southwestern Medical Center · USHumanN (United States) · USHoward Hughes Medical Institute · USWarsaw University of Life Sciences · PL

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
Measuring Lipid Flux By Ultra High Resolution Mass SpectrometryR35GM137991 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MITSCHE, MATTHEW ALVIN · 2020 to 2024
$2.2M
Functions and regulation of endoplasmic reticulum-plasma membrane junctionsR01GM113079 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIOU, JEN · 2016 to 2020
$1.6M
Proteostasis, AMPylation and the Unfolded Protein repsonse (UPR)R01GM115188 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2015 to 2018
$1.2M
NHLBI NIH HHS P01 HL020948NIGMS NIH HHS R01 GM113079NIGMS NIH HHS R35 GM137991NIH HHS PO1 HL20948NIH HHS R01 GM115188NIH HHS RO1 GM113079Welch Foundation I-1561
6 · The paper itself

Abstract

Pathogens find diverse niches for survival including inside a host cell where replication occurs in a relatively protective environment.

Indexed as

Bacterial ProteinsCholesterolEsterificationFatty AcidsGenomic IslandsLipaseType III Secretion SystemsVibrio parahaemolyticusBacterial ProteinsCholesterolFatty AcidsLipaseType III Secretion Systemscholesterol homeostasisegressinfectious diseaseinvasionmicrobiologyT3SSvibrio parahaemolyticusVPA0226

Identifiers

PMID32808593
PMCPMC7434443
OpenAlexW3050678364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.