ArticleJournal of the American Heart Association2020
Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
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Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- SORBS2 regulates diastolic function through cytoskeletal networks and calcium handling.Communications biology · 2026Article
- SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold-Mediated Regulation.Journal of cellular and molecular medicine · 2026Review
- Impact of Sorbs2 dysfunction on cardiovascular diseases.Biochimica et biophysica acta. Molecular basis of disease · 2025Review
- Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition.Cardiovascular research · 2025Article
- Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling.Frontiers in cardiovascular medicine · 2025Article
- Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection.Journal of molecular and cellular cardiology plus · 2024Article
- Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes.Circulation research · 2024Article
- Increased cardiac macrophages inFrontiers in genetics · 2024Article
- Genomic Analysis Reveals Candidate Genes Underlying Sex-Linked Eyelid Coloboma, Feather Color Traits, and Climatic Adaptation in Huoyan Geese.Animals : an open access journal from MDPI · 2023Article
- Arrhythmogenic Cardiomyopathy: from Preclinical Models to Genotype-phenotype Correlation and Pathophysiology.Stem cell reviews and reports · 2023Review
- Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models.Genes · 2023Review
- Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy.Disease models & mechanisms · 2023Article
- Article
- Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy.International journal of molecular sciences · 2023Review
- Epigenome-wide DNA methylation in leukocytes and toenail metals: The normative aging study.Environmental research · 2023Article
- Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play.Frontiers in cardiovascular medicine · 2023Review
- Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia.Journal of anatomy · 2023Review
- Article
- Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.Journal of the American Heart Association · 2022Article
- The role of junctophilin proteins in cellular function.Physiological reviews · 2022Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Yonghe DingDepartment of Biochemistry and Molecular Biology Mayo Clinic Rochester MN.
Jingchun YangDepartment of Biochemistry and Molecular Biology Mayo Clinic Rochester MN.
Peng ChenHubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders Division of Cardiology Departments of Internal Medicine and Genetic Diagnosis Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Tong LuDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN.
Kunli JiaoDepartment of Biochemistry and Molecular Biology Mayo Clinic Rochester MN.
David J TesterDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN.
John R GiudicessiDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN.
Kai JiangDivision of Nephrology and Hypertension Mayo Clinic Rochester MN.
Michael J AckermanDepartment of Cardiovascular Medicine (Division of Heart Rhythm Services) Mayo Clinic Rochester MN.
Yigang LiDivision of Cardiology Xinhua Hospital Shanghai Jiaotong University Shanghai China.
Dao Wu WangState Key Laboratory of Reproductive Medicine Clinical Center of Reproductive Medicine and Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing China.
HoN-Chi LeeDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN.
Dao Wen WangHubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders Division of Cardiology Departments of Internal Medicine and Genetic Diagnosis Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Xiaolei XuDepartment of Biochemistry and Molecular Biology Mayo Clinic Rochester MN.
Mayo Clinic in Arizona · USMayo Clinic · USTongji Hospital · CNJiangsu Province Hospital · CNXinHua Hospital · CN
Funding
Systematic Vertebrate Functional GenomicsR01GM063904 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EKKER, STEPHEN CARL · 2001 to 2025
$10.7MGenetic Studies of Sarcomere-based Cardiac Diseases (Diversity Supplement)R01HL081753 · NHLBI · MAYO CLINIC ROCHESTER · PI XU, XIAOLEI · 2005 to 2025
$7.8MEpicardial remodeling in cardiomyopathy and cardiac agingR01HL107304 · NHLBI · MAYO CLINIC ROCHESTER · PI Xiaolei Xu · 2011 to 2026
$6.6MType 2 Diabetes and Vascular BK Channel RegulationR01HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2003 to 2018
$4.8MSystematic Vertebrate Functional GenomicsR56GM063904 · NIGMS · MAYO CLINIC ROCHESTER · PI EKKER, STEPHEN CARL · 2009 to 2010
$611kRegulation of Vascular BK Channels in DiabetesR56HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2008 to 2008
$378kNHLBI NIH HHS R01 HL074180NHLBI NIH HHS R01 HL081753NHLBI NIH HHS R01 HL107304NHLBI NIH HHS R56 HL074180NIGMS NIH HHS R01 GM063904NIGMS NIH HHS R56 GM063904
Abstract
Background
Indexed as
Adaptor Proteins, Signal TransducingAdultAgedAnimalsArrhythmias, CardiacArrhythmogenic Right Ventricular DysplasiaCardiomyopathiesCase-Control StudiesDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHumansMaleMiceMice, KnockoutMiddle AgedAdaptor Proteins, Signal TransducingRNA-Binding ProteinsSORBS2 protein, humanSorbs2 protein, mousearrhythmogenic cardiomyopathyintercalated discsorbin and SH3 domain‐containing 2susceptibility gene
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.