ArticleJournal of the American Chemical Society2020
Fluorous Soluble Cyanine Dyes for Visualizing Perfluorocarbons in Living Systems.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- π-Stacked supramolecular contact ion pairs prohibit quenching and provide control of symmetry in fluorescent dyes.Chemical science · 2026Article
- A fluorous-phase oxygen optical nanosensor for mitigating redox-active microbial metabolite interference.The Analyst · 2026Article
- Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging.Journal of the American Chemical Society · 2026Article
- Counterion-Enhanced Brightness of Fluorous-Soluble Heptamethine Cyanine Dyes for Near- and Shortwave Infrared Fluorescence Imaging.Chemical & biomedical imaging · 2026Article
- STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses.Scientific reports · 2025Article
- Fluorous-Phase- and Chiral-Axis-Enhanced Fluorescent Sensitivity and Chemoselectivity for Cysteine Recognition.Organic letters · 2025Article
- Non-Ionic Fluorosurfactants for Droplet-Based in vivo Applications.Angewandte Chemie (International ed. in English) · 2024Article
- Counterion Exchange Enhances the Brightness and Photostability of a Fluorous Cyanine Dye.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- A nuclear jamming transition in vertebrate organogenesis.Nature materials · 2024Article
- Photophysics of fluorescent nanoparticles based on organic dyes - challenges and design principles.Chemical science · 2024Review
- In situ quantification of osmotic pressure within living embryonic tissues.Nature communications · 2023Article
- Innovative Real-Time Flow Sensor Using Detergent-Free Complex Emulsions with Dual-Emissive Semi-Perfluoroalkyl Substituted Α-Cyanostilbene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- In vitro Quality Assessments of Perfluorocarbon Nanoemulsions for Near-infrared Fluorescence Imaging of Inflammation in Preclinical Models.Bio-protocol · 2023Article
- Perfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia.International journal of molecular sciences · 2023Article
- Experimentally Calibrated Computational Prediction Enables Accurate Fine-Tuning of Near-Infrared Rhodamines for Multiplexing.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging.Angewandte Chemie (International ed. in English) · 2023Article
- Near-Infrared Probes for Biothiols (Cysteine, Homocysteine, and Glutathione): A Comprehensive Review.ACS omega · 2023Review
- Macromolecular Crowding as an Intracellular Stimulus for Responsive Nanomaterials.Journal of the American Chemical Society · 2022Article
- Facile synthesis of near-infrared responsive on-demand oxygen releasing nanoplatform for precise MRI-guided theranostics of hypoxia-induced tumor chemoresistance and metastasis in triple negative breast cancer.Journal of nanobiotechnology · 2022Article
- Emergent Fluorous Molecules and Their Uses in Molecular Imaging.Accounts of chemical research · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The bioorthogonal nature of perfluorocarbons provides a unique platform for introducing dynamic nano- and microdroplets into cells and organisms. To monitor the localization and deformation of the droplets, fluorous soluble fluorophores that are compatible with standard fluorescent protein markers and applicable to cells, tissues, and small organisms are necessary. Here, we introduce fluorous cyanine dyes that represent the most red-shifted fluorous soluble fluorophores to date. We study the effect of covalently appended fluorous tags on the cyanine scaffold and evaluate the changes in photophysical properties imparted by the fluorous phase. Ultimately, we showcase the utility of the fluorous soluble pentamethine cyanine dye for tracking the localization of perfluorocarbon nanoemulsions in macrophage cells and for measurements of mechanical forces in multicellular spheroids and zebrafish embryonic tissues. These studies demonstrate that the red-shifted cyanine dyes offer spectral flexibility in multiplexed imaging experiments and enhanced precision in force measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.