ReviewNeurogastroenterology and motility2020
Irritable Bowel Syndrome: Straightening the road from the Rome criteria.
Review in Neurogastroenterology and motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Silent Struggles Within: Alexithymia Unveiled in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.Journal of neurogastroenterology and motility · 2024Pooled it
- Effect of oat or rice flour on pulse-induced gastrointestinal symptoms and breath hydrogen in subjects sensitive to pulses and controls - a randomised cross-over trial with two parallel groups.The British journal of nutrition · 2022Trial
- Integrated multi-omic and symptom clustering reveals lower-gastrointestinal disorders of gut-brain interaction heterogeneity.Gut microbes · 2026Article
- Effect of combined continuity care guided by Orem's self-care model and low FODMAP diet on gut microbiota composition and symptoms in patients with irritable bowel syndrome.BMC gastroenterology · 2026Article
- Rethinking Complex Care Using Participatory Medical Cognition and User-Driven Learning Amidst Multimorbidity: Participatory Action Research Study.Journal of participatory medicine · 2025Article
- Clinical practice guidelines for the diagnosis of constipation-predominant irritable bowel syndrome and functional constipation in adults: a scoping review.BMC gastroenterology · 2025Article
- Prevalence of functional diarrhea in children and adolescents.Neurogastroenterology and motility · 2025Article
- Moving beyond Symptom Criteria to Diagnose and Treat Functional Disorders: Patient-Reported Symptoms of Functional Lower Gastrointestinal Disorders Correlate Poorly with Objective Assessment of Luminal Contents Seen on Intestinal Ultrasound.Journal of clinical medicine · 2024Article
- Potential Value of Biomarker-Based Approaches for Evaluation and Management of Costly Functional Gastrointestinal Diseases.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Review
- Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis.BMC gastroenterology · 2023Article
- Fecal Calprotectin Elevations Associated with Food Intolerance/Malabsorption Are Significantly Reduced with Targeted Diets.Nutrients · 2023Article
- Chaihu-Guizhi-Ganjiang Decoction is more efficacious in treating irritable bowel syndrome than Dicetel according to metabolomics analysis.Chinese medicine · 2022Article
- Effect ofWorld journal of gastroenterology · 2022Observational
- Rectal Evacuation Disorders in Patients Presenting With Chronic Functional Diarrhea.Gastro hep advances · 2022Review
- Prevalence, clinical characteristics, and management of irritable bowel syndrome in Vietnam: A scoping review.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Editorial: Pharmacological Treatments Affecting Gastro-Intestinal Motility in Man.Frontiers in pharmacology · 2021Article
- Obesity Exacerbates Irritable Bowel Syndrome-Related Sleep and Psychiatric Disorders in Women With Polycystic Ovary Syndrome.Frontiers in endocrinology · 2021Article
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Funding
Abstract
A sequence of consensus-based Rome criteria for irritable bowel syndrome (IBS) has been published since 1989. The fundamental definition based on abdominal pain in association with bowel dysfunction has been consistent. However, two major changes occurred in the Rome II and IV criteria. The former change involved "splitting off" of symptoms that were not consistently associated with pain, such as functional, constipation, diarrhea, and bloating. In Rome IV, the main changes were the exclusion of discomfort (in contrast to pain) and the more stringent frequency criteria for the pain to be eligible for diagnosis of IBS (specifically, on average, at least 1 day per week in the last 3 months). Validation studies of the consensus, symptom-based criteria have identified multiple deficiencies that question the rationale for "splitting" the different syndromes, and favor a simpler identification of the classical symptoms of abdominal pain, bowel dysfunction, and bloating, and exclusion of alarm symptoms. Advances in the identification of actionable biomarkers related to the symptoms suggestive of functional gastrointestinal disorders have the potential to usher a change in practice from positive diagnosis of symptom complexes followed by empirical treatment to identification of the mechanisms causing the symptoms and targeted therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.