Evidence map›Paper›PMID 32808407›Full record

ArticleNMR in biomedicine2020

Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations.

Roland Kreis, Vincent Boer, In-Young Choi, Cristina Cudalbu, Robin A de Graaf, Charles Gasparovic, Arend Heerschap, Martin Krššák, Bernard Lanz, Andrew A Maudsley and 10 more

Abstract read
In one paragraph

Article in NMR in biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  9. Postexercise Lactate Clearance, TMagnetic resonance in medicine · 2026
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  11. A Novel 9-ChannelMagnetic resonance in medicine · 2026
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  13. Review
  14. A Digital Phantom for MR Spectroscopy Data Simulation.Magnetic resonance in medicine · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Roland KreisDepartment of Radiology, Neuroradiology, and Nuclear Medicine and Department of Biomedical Research, University Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8618-6875
Vincent BoerDanish Research Centre for Magnetic Resonance, Funktions- og Billeddiagnostisk Enhed, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.ORCID https://orcid.org/0000-0001-6026-3134
In-Young ChoiDepartment of Neurology, Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Cristina CudalbuCentre d'Imagerie Biomedicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4582-2465
Robin A de GraafDepartment of Radiology and Biomedical Imaging & Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-6570-7010
Charles GasparovicThe Mind Research Network, Albuquerque, New Mexico, USA.ORCID https://orcid.org/0000-0002-4433-7815
Arend HeerschapDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Martin KrššákDivision of Endocrinology and Metabolism, Department of Internal Medicine III & High Field MR Centre, Department of Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-9717-803X
Bernard LanzLaboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-5136-075X
Andrew A MaudsleyDepartment of Radiology, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID https://orcid.org/0000-0001-7653-3063
Martin MeyerspeerCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-0295-8218
Jamie NearDouglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0003-3516-936X
Gülin ÖzCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-5769-183X
Stefan PosseDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.ORCID https://orcid.org/0000-0002-4816-080X
Johannes SlotboomDepartment of Radiology, Neuroradiology, and Nuclear Medicine, University Hospital Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-5121-9852
Melissa TerpstraCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Ivan TkáčCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-5054-0150
Martin WilsonCentre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK.
Wolfgang BognerHigh Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-0130-3463
Experts' Working Group on Terminology for MR Spectroscopy

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
Development and Maintenance of Software for MR Spectroscopic ImagingR01EB016064 · NIBIB · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAUDSLEY, ANDREW A. · 2013 to 2021
$2.0M
Austrian Science Fund (FWF) I 1743-B13Austrian Science Fund (FWF) P 30701-B27NCATS NIH HHS UL1 TR001863NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NIBIB NIH HHS R01 EB016064NIH HHS R01EB016064NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS080816Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_173222Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030-175984
6 · The paper itself

Abstract

With a 40-year history of use for in vivo studies, the terminology used to describe the methodology and results of magnetic resonance spectroscopy (MRS) has grown substantially and is not consistent in many aspects. Given the platform offered by this special issue on advanced MRS methodology, the authors decided to describe many of the implicated terms, to pinpoint differences in their meanings and to suggest specific uses or definitions. This work covers terms used to describe all aspects of MRS, starting from the description of the MR signal and its theoretical basis to acquisition methods, processing and to quantification procedures, as well as terms involved in describing results, for example, those used with regard to aspects of quality, reproducibility or indications of error. The descriptions of the meanings of such terms emerge from the descriptions of the basic concepts involved in MRS methods and examinations. This paper also includes specific suggestions for future use of terms where multiple conventions have emerged or coexisted in the past.

Indexed as

MR spectroscopic imaging, MR spectroscopy, spectroscopic quantitation, standardization

Identifiers

PMID32808407
PMCPMC7887137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.