ArticleCerebral cortex (New York, N.Y. : 1991)2021
Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- MRI-based atrophy subtypes in a young memory clinic cohort: associations with clinical and biomarker profiles.Alzheimer's research & therapy · 2026Article
- Brain-rejuvenating factor TIMP2 is associated with brain health and neuroprotective lifestyle in aged subjects.medRxiv : the preprint server for health sciences · 2025Article
- Regional tau PET patterns predict prospective domain-specific cognitive decline in early symptomatic Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer's disease by repressing FoxO1 gene expression.Scientific reports · 2025Article
- "Fill States": PET-derived Markers of the Spatial Extent of Alzheimer Disease Pathology.Radiology · 2025Observational
- Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2024Article
- The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight.Nature reviews. Neuroscience · 2023Review
- Psychological stress is associated with arterial inflammation in people living with treated HIV infection.Brain, behavior, and immunity · 2023Article
- Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.Acta neuropathologica communications · 2023Article
- Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.Journal of molecular biology · 2023Article
- Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease.Human brain mapping · 2023Article
- Longitudinal Spatial Relationships Between Atrophy and Hypometabolism Across the Alzheimer's Disease Continuum.Journal of Alzheimer's disease : JAD · 2023Article
- Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease.Brain : a journal of neurology · 2022Article
- Probing individual-level structural atrophy in frontal glioma patients.Neurosurgical review · 2022Article
- Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
A deeper understanding of the spatial relationships of β-amyloid (Aβ), tau, and neurodegeneration in Alzheimer's disease (AD) could provide insight into pathogenesis and clinical trial design. We included 81 amyloid-positive patients (age 64.4 ± 9.5) diagnosed with AD dementia or mild cognitive impairment due to AD and available 11C-PiB (PIB), 18F-Flortaucipir (FTP),18F-FDG-PET, and 3T-MRI, and 31 amyloid-positive, cognitively normal participants (age 77.3 ± 6.5, no FDG-PET). W-score voxel-wise deviation maps were created and binarized for each imaging-modality (W > 1.64, P < 0.05) adjusting for age, sex, and total intracranial volume (sMRI-only) using amyloid-negative cognitively normal adults. For symptomatic patients, FDG-PET and atrophy W-maps were combined into neurodegeneration maps (ND). Aβ-pathology showed the greatest proportion of cortical gray matter suprathreshold voxels (spatial extent) for both symptomatic and asymptomatic participants (median 94-55%, respectively), followed by tau (79-11%) and neurodegeneration (41-3%). Amyloid > tau > neurodegeneration was the most frequent hierarchy for both groups (79-77%, respectively), followed by tau > amyloid > neurodegeneration (13-10%) and amyloid > neurodegeneration > tau (6-13%). For symptomatic participants, most abnormal voxels were PIB+/FTP+/ND- (median 35%), and the great majority of ND+ voxels (91%) colocalized with molecular pathology. Amyloid spatially exceeded tau and neurodegeneration, with individual heterogeneities. Molecular pathology and neurodegeneration showed a progressive overlap along AD course, indicating shared vulnerabilities or synergistic toxic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.