ReviewNature metabolism2020
Exercise and cardiac health: physiological and molecular insights.
Review in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Physical activity in patients receiving peritoneal dialysis: a systematic evaluation and meta-analysis.International urology and nephrology · 2025Pooled it
- Impact of Secondary Amenorrhea on Cardiovascular Disease Risk in Physically Active Women: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2024Pooled it
- Association between Urban Greenspace and Health: A Systematic Review of Literature.International journal of environmental research and public health · 2021Pooled it
- Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults.Nutrients · 2025Trial
- Effect of pilates on the physical and mental health of drug-dependent individuals - a randomized controlled trial.BMC psychiatry · 2025Trial
- Efficacy ofNutrients · 2024Trial
- Individual cardiovascular responsiveness to work-matched exercise within the moderate- and severe-intensity domains.European journal of applied physiology · 2021Trial
- Impact on Health-Related Quality of Life after Different Aerobic Exercise Programs in Physically Inactive Adults with Overweight/Obesity and Primary Hypertension: Data from the EXERDIET-HTA Study.International journal of environmental research and public health · 2020Trial
- Leveraging neural network models for drug repurposing: a case study on cardiac hypertrophy.Scientific reports · 2026Article
- Exercise ModulatesInternational journal of molecular sciences · 2026Article
- Mechanoreceptor-mediated adaptations to physical exercise: from acute responses to long-term training effects.Cellular and molecular life sciences : CMLS · 2026Review
- FTO-Eci1 Axis Mediates Exercise-Induced Cardioprotection in Pressure Overload Mice.Biomolecules · 2026Article
- Evidence of early subclinical atherosclerosis in women with exercise-induced hypothalamic amenorrhea.Human reproduction open · 2026Article
- Engineered Muscle Tissue Analysis of Irisin Protection Against Glucocorticoid- and Cancer Cachexia-Induced Muscle Wasting and Cardiotoxicity.Biochip journal · 2026Article
- Regular versus Irregular Exercise Differentially Modulates Hippocampal-Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Exercise intensity and cardiac metabolic adaptations in elderly heart failure rehabilitation: A review.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Plasma cardiovascular stress biomarkers response to marathon running.Sports medicine and health science · 2025Article
- Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study.Journal of the American Heart Association · 2025Article
- Nonexercise Estimation of V̇OEuropean journal of sport science · 2025Article
- Cardiac CapZ Regulation During Acute Exercise in Female Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cardiac benefits of exercise have been recognized for centuries. Studies have undisputedly shown that regular exercise is beneficial for the cardiovascular system in young, old, healthy and diseased populations. For these reasons, physical activity has been recommended worldwide for cardiovascular disease prevention and treatment. Although the benefits of exercise are clear, understanding of the molecular triggers that orchestrate these effects remains incomplete and has been a topic of intense research in recent years. Here, we provide a comprehensive review of the cardiac effects of physical activity, beginning with a brief history of exercise in cardiovascular medicine and then discussing seminal work on the physiological effects of exercise in healthy, diseased and aged hearts. Later, we revisit pioneering work on the molecular mechanisms underlying the cardiac benefits of exercise, and we conclude with our view on the translational potential of this knowledge as a powerful platform for cardiovascular disease drug discovery.
Indexed as
Identifiers
32807982What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.