ArticleNature methods2020
Scale-free vertical tracking microscopy.
Article in Nature methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- High connectivity and genetic diversity in the Endangered endemic white-spotted sand bass 'camotillo' (Paralabrax albomaculatus) within the Galápagos Marine Reserve.BMC ecology and evolution · 2026Article
- An Advanced Mobile Laboratory to enable field-based microbial ecology and cell biology across scales.bioRxiv : the preprint server for biology · 2026Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.Communications biology · 2026Article
- Cilia-driven epithelial folding and unfolding in an early diverging animal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Plankton active response to turbulence enables efficient transport.The Journal of experimental biology · 2025Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.bioRxiv : the preprint server for biology · 2025Article
- The immeasurable value of plankton to humanity.Bioscience · 2025Article
- Biogel scavenging slows the sinking of organic particles to the ocean depths.Nature communications · 2025Article
- Orthogonal-view microscope for the biomechanics investigations of aquatic organisms.HardwareX · 2024Article
- Trackoscope: A low-cost, open, autonomous tracking microscope for long-term observations of microscale organisms.PloS one · 2024Article
- Methods and Measures for Investigating Microscale Motility.Integrative and comparative biology · 2023Review
- Thermotaxis in an apolar, non-neuronal animal.Journal of the Royal Society, Interface · 2023Article
- Active sinking particles: sessile suspension feeders significantly alter the flow and transport to sinking aggregates.Journal of the Royal Society, Interface · 2023Article
- SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies ofBiology · 2023Article
- Article
- Simultaneous visualization of flow fields and oxygen concentrations to unravel transport and metabolic processes in biological systems.Cell reports methods · 2022Article
- Live imaging of echinoderm embryos to illuminate evo-devo.Frontiers in cell and developmental biology · 2022Article
- Manu Prakash.Nature methods · 2020Article
- Plankton in a hamster wheel.Nature methods · 2020Article
- A materials-science perspective on tackling COVID-19.Nature reviews. Materials · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
The behavior and microscale processes associated with freely suspended organisms, along with sinking particles underlie key ecological processes in the ocean. Mechanistically studying such multiscale processes in the laboratory presents a considerable challenge for microscopy: how to measure single cells at microscale resolution, while allowing them to freely move hundreds of meters in the vertical direction? Here we present a solution in the form of a scale-free, vertical tracking microscope, based on a 'hydrodynamic treadmill' with no bounds for motion along the axis of gravity. Using this method to bridge spatial scales, we assembled a multiscale behavioral dataset of nonadherent planktonic cells and organisms. Furthermore, we demonstrate a 'virtual-reality system for single cells', wherein cell behavior directly controls its ambient environmental parameters, enabling quantitative behavioral assays. Our method and results exemplify a new paradigm of multiscale measurement, wherein one can observe and probe macroscale and ecologically relevant phenomena at microscale resolution. Beyond the marine context, we foresee that our method will allow biological measurements of cells and organisms in a suspended state by freeing them from the confines of the coverslip.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.