ReviewNature plants2020
Genetic dissection of the auxin response network.
Review in Nature plants, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Early "Rootprints" of Plant Terrestrialization: Selaginella Root Development Sheds Light on Root Evolution in Vascular Plants.Frontiers in plant science · 2021Pooled it
- The miR167-ARF8 module coordinates stamen-pistil development and fruit set in tomato.The New phytologist · 2026Article
- Aux/IAAs: specificity and redundancy.Plant signaling & behavior · 2025Review
- Characterization of a KANADI-like transcription factor that suppresses pear anthocyanin biosynthesis.Horticulture research · 2025Article
- A KNOTTED1-LIKE HOMEOBOX PROTEIN1-interacting transcription factor SlGATA6 maintains the auxin-response gradient to inhibit abscission.Science advances · 2025Article
- Genome-wide characterization ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Article
- Switching action modes of miR408-5p mediates auxin signaling in rice.Nature communications · 2024Article
- Disruption of the Contents of Endogenous Hormones Cause Pollen Development Obstruction and Abortion in Male-Sterile Hybrid Lily Populations.Plants (Basel, Switzerland) · 2023Article
- Modulating auxin response stabilizes tomato fruit set.Plant physiology · 2023Article
- Four class A AUXIN RESPONSE FACTORs promote tomato fruit growth despite suppressing fruit set.Nature plants · 2023Article
- Polar auxin transport modulates early leaf flattening.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis.Nature communications · 2022Article
- Auxin-driven ecophysiological diversification of leaves in domesticated tomato.Plant physiology · 2022Article
- Fine Mapping and Candidate Gene Prediction of Tuber Shape ControllingInternational journal of molecular sciences · 2022Article
- The Systems and Synthetic Biology of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- A Phloem-ExpressedFrontiers in plant science · 2022Article
- Auxin Does the SAMba: Auxin Signaling in the Shoot Apical Meristem.Cold Spring Harbor perspectives in biology · 2021Review
- Auxin-Regulated Lateral Root Organogenesis.Cold Spring Harbor perspectives in biology · 2021Review
- Expansion and innovation in auxin signaling: where do we grow from here?Development (Cambridge, England) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expansion of gene families during evolution, which can generate functional overlap or specialization among their members, is a characteristic feature of signalling pathways in complex organisms. For example, families of transcriptional activators and repressors mediate responses to the plant hormone auxin. Although these regulators were identified more than 20 years ago, their overlapping functions and compensating negative feedbacks have hampered their functional analyses. Studies using loss-of-function approaches in basal land plants and gain-of-function approaches in angiosperms have in part overcome these issues but have still left an incomplete understanding. Here, we propose that renewed emphasis on genetic analysis of multiple mutants and species will shed light on the role of gene families in auxin response. Combining loss-of-function mutations in auxin-response activators and repressors can unravel complex outputs enabled by expanded gene families, such as fine-tuned developmental outcomes and robustness. Similar approaches and concepts may help to analyse other regulatory pathways whose components are also encoded by large gene families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.