ArticleNature medicine2020
Articular cartilage regeneration by activated skeletal stem cells.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 3 pooled it
39.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
190 citing papers in PubMed, 3 syntheses or guidelines pooled it, 347 citations in OpenAlex.
- Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions.Journal of translational medicine · 2024Pooled it
- Naturally Occurring Osteoarthritis Features and Treatments: Systematic Review on the Aged Guinea Pig Model.International journal of molecular sciences · 2022Pooled it
- Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.Advanced healthcare materials · 2021Pooled it
- ADSC-enriched adipose extract alleviates cartilage fibrosis in temporomandibular joint osteoarthritis by inhibiting chondrocyte senescence.Journal of translational medicine · 2025Trial
- Type II collagen as a material-mediated instructive platform: Cartilage regeneration and fibrosis suppression via the Tp63-Cytl1 axis.Materials today. Bio · 2026Article
- IRF2BP2-FOSL2 interaction regulates SOX9-mediated cartilage regeneration in osteoarthritis models.The Journal of clinical investigation · 2026Article
- Review
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- The role and therapeutic potential of vitamins in fracture healing.Nutrition journal · 2026Review
- Two-Year Clinical Outcome of Using Biphasic Osteochondral Constructs in the Treatment of Patients with Mild-to-Moderate-Stage Osteoarthritis of the Knee.Bioengineering (Basel, Switzerland) · 2026Article
- Advancing Prevention and Treatment of Ankle Osteoarthritis: A Translational Clinical Roadmap from the 2026 AOFAS/Arthritis Foundation Ankle Arthritis Think Tank.Foot & ankle orthopaedics · 2026Review
- Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives.Journal of orthopaedic translation · 2026Review
- Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.Bioactive materials · 2026Article
- WTAP-Mediated mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-Content Analysis of 3D Chondrogenic Pellets Derived from Primary Cells In Vitro.Biomedicines · 2026Article
- Chondrocytes in fracture healing: A review of chondrocyte journey.Chinese medical journal · 2026Review
- OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres.International journal of oral science · 2026Article
- A novel non-invasive approach monitoring skeletal stem cell function throughJournal of orthopaedic translation · 2026Article
- Type E endothelial cells orchestrate embryonic skeletogenesis via chondrogenic priming of skeletal progenitors.Journal of orthopaedic translation · 2026Article
- Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by'Actum ne agas'.2021
Authors and funding
21 authors at 7 institutions in 4 countries.
Matthew P MurphyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Lauren S KoepkeDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Michael T LopezDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Xinming TongDepartment of Bioengineering, Stanford University, Palo Alto, CA, USA.
Thomas H AmbrosiDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Gunsagar S GulatiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2798-6220
Owen MarecicInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1540-7191
Yuting WangDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Ryan C RansomInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Malachia Y HooverInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Holly SteiningerDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Liming ZhaoDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Marcin P WalkiewiczDepartment of Stanford Nano Shared Facilities, Stanford University, Palo Alto, CA, USA.
Natalina QuartoDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Benjamin LeviDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Derrick C WanDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9077-7467
Stuart B GoodmanDepartment of Bioengineering, Stanford University, Palo Alto, CA, USA.
Fan YangDepartment of Bioengineering, Stanford University, Palo Alto, CA, USA.
Michael T LongakerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. longaker@stanford.edu.ORCID http://orcid.org/0000-0003-1430-8914
Charles K F ChanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. chazchan@stanford.edu.ORCID http://orcid.org/0000-0001-6570-7574
Stanford University · USPalo Alto University · USTongji Hospital · CNCalifornia Institute for Regenerative Medicine · USInstitute for Stem Cell Biology and Regenerative Medicine · INManchester Academic Health Science Centre · GBUniversity of Michigan · US
Funding
Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0MInduced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2MGraduate Training in Stem Cell Biology and Regenerative MedicineT32GM119995 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2021
$2.0MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MIdentifying the human skeletal stem cell.R01DE027323 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2018 to 2022
$1.9MCellular and Mechanical Mechanisms Regulating Mandibular Distraction OsteogenesisR01DE026730 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2017 to 2021
$1.9MTargeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5MDeveloping New Diagnostic and Timed, TAK1 Specific Treatment Strategies for Trauma Induced Heterotopic OssificationR01GM123069 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2020
$1.2MEnhanced Calvarial Regeneration Via RNAi-Mediated Suppression of BMP AntagonismR21DE019274 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2008 to 2009
$768kMechanisms of Skeletal Stem Cell AgingR00AG049958 · NIA · STANFORD UNIVERSITY · PI CHAN, CHARLES KF · 2018 to 2020
$747kBio-AFM for combined light and atomic force imagingS10OD021514 · OD · STANFORD UNIVERSITY · PI DUNN, ALEXANDER R · 2016 to 2016
$513kEnhancing Bcl-2 Expression for Bone Regeneration.R21DE024230 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2014 to 2015
$443kHoward Hughes Medical InstituteNHLBI NIH HHS U01 HL099776NIAMS NIH HHS R01 AR071379NIA NIH HHS K99 AG049958NIA NIH HHS R00 AG049958NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01 DE026730NIDCR NIH HHS R01 DE027323NIDCR NIH HHS R21 DE019274NIDCR NIH HHS R21 DE024230NIDCR NIH HHS R56 DE025597NIDCR NIH HHS U24 DE026914NIGMS NIH HHS R01 GM123069NIGMS NIH HHS T32 GM119995NIH HHS S10 OD021514
Abstract
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage
Indexed as
AdultAnimalsCartilage, ArticularCell DifferentiationCells, CulturedChondrocytesChondrogenesisFetal Tissue TransplantationFetusHeterograftsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, Transgenic
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.