ArticleHeredity2021
DNA methylation mediates differentiation in thermal responses of Pacific oyster (Crassostrea gigas) derived from different tidal levels.
Article in Heredity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- Whole genome DNA methylation atlas of the scallop Patinopecten yessoensis.Scientific data · 2026Article
- Article
- DNA methylation site loss for plasticity-led novel trait genetic fixation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub.Ecology and evolution · 2026Article
- Article
- Prior exposure to hypoxia alters DNA methylation patterns in the eastern oyster.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic Responses to Anthropogenic Versus Natural Sources of Oil Exposure Differ in Wild Arctic Seabird Populations.Evolutionary applications · 2025Article
- DNA Methylation Patterns Provide Insights into the Epigenetic Regulation of Intersex Formation in the Chinese Mitten Crab (International journal of molecular sciences · 2025Article
- DNA Methylation of Somatic Tissues in Oysters is Influenced by Sex and Heredity.Marine biotechnology (New York, N.Y.) · 2025Article
- Environmental influence on single methylation variation sites (SMVs) in the large yellow croaker (Larimichthys crocea): identification and correlation analysis.Molecular biology reports · 2024Article
- Parental thermal environment controls the offspring phenotype in Brook charr (Salvelinus fontinalis): insights from a transcriptomic study.G3 (Bethesda, Md.) · 2024Article
- Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Plasticity and associated epigenetic mechanisms play a role in thermal evolution during range expansion.Evolution letters · 2024Article
- Heatwave resilience of juvenile white sturgeon is associated with epigenetic and transcriptional alterations.Scientific reports · 2023Article
- High temperature influences DNA methylation and transcriptional profiles in sea urchins (Strongylocentrotus intermedius).BMC genomics · 2023Article
- A tool for rapid, automated characterization of population epigenomics in plants.Scientific reports · 2023Article
- Experimental DNA Demethylation Reduces Expression Plasticity and Thermal Tolerance in Pacific Oysters.Marine biotechnology (New York, N.Y.) · 2023Article
- Epigenetic and Genetic Population Structure is Coupled in a Marine Invertebrate.Genome biology and evolution · 2023Article
- Acute heat priming promotes short-term climate resilience of early life stages in a model sea anemone.PeerJ · 2023Article
- The mechanisms and factors that induce trained immunity in arthropods and mollusks.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms such as DNA methylation have the potential to affect organism acclimatization and adaptation to environmental changes by influencing their phenotypic plasticity; however, little is known about the role of methylation in the adaptive phenotypic divergence of marine invertebrates. Therefore, in this study, a typical intertidal species, the Pacific oyster (Crassostrea gigas), was selected to investigate the epigenetic mechanism of phenotypic plasticity in marine invertebrates. Intertidal and subtidal oysters subjected to one-generation common garden experiments and exhibited phenotypic divergence were used. The methylation landscape of both groups of oysters was investigated under temperate and high temperature. The two tidal oysters exhibited divergent methylation patterns, regardless of the temperature, which was mainly original environment-induced. Intertidal samples exhibited significant hypomethylation and more plasticity of methylation in response to heat shock, while subtidal samples showed hypermethylation and less plasticity. Combined with RNA-seq data, a positive relationship between methylation and expression in gene bodies was detected on a genome-wide scale. In addition, approximately 11% and 7% of differentially expressed genes showed significant methylation variation under high temperatures in intertidal and subtidal samples, respectively. Genes related to apoptosis and organism development may be regulated by methylation in response to high temperature in intertidal oysters, whereas oxidation-reduction and ion homeostasis-related genes were involved in subtidal oysters. The results also suggest that DNA methylation mediates phenotypic divergence in oysters adapting to different environments. This study provides new insight into the epigenetic mechanisms underlying phenotypic plasticity in adaptation to rapid climate change in marine organisms.
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