ArticleScientific reports2020
Electrochemical immunosensor with Cu(I)/Cu(II)-chitosan-graphene nanocomposite-based signal amplification for the detection of newcastle disease virus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 44 citations in OpenAlex.
- Solid-State On-Substrate Synthesis of Size-Controlled CuPt@CuACS applied materials & interfaces · 2025Article
- Electrode Modification in Viral Biosensors: A Review.Current medicinal chemistry · 2025Review
- Explore how immobilization strategies affected immunosensor performance by comparing four methods for antibody immobilization on electrode surfaces.Scientific reports · 2022Article
- An Enzyme-Free Sandwich Amperometry-Type Immunosensor Based on Au/Pt Nanoparticle-Functionalized Graphene for the Rapid Detection of Avian Influenza Virus H9 Subtype.Nanoscale research letters · 2022Article
- Review detection of Newcastle disease virus.Frontiers in veterinary science · 2022Review
- Two-dimensional material-based virus detection.Science China. Chemistry · 2022Review
- Pathogen detection with electrochemical biosensors: Advantages, challenges and future perspectives.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2021Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
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Abstract
An electrochemical immunoassay for the ultrasensitive detection of Newcastle disease virus (NDV) was developed using graphene and chitosan-conjugated Cu(I)/Cu(II) (Cu(I)/Cu(II)-Chi-Gra) for signal amplification. Graphene (Gra) was used for both the conjugation of an anti-Newcastle disease virus monoclonal antibody (MAb/NDV) and the immobilization of anti-Newcastle disease virus polyclonal antibodies (PAb/NDV). Cu(I)/Cu(II) was selected as an electroactive probe, immobilized on a chitosan-graphene (Chi-Gra) hybrid material, and detected by differential pulse voltammetry (DPV) after a sandwich-type immune response. Because Gra had a large surface area, many antibodies were loaded onto the electrochemical immunosensor to effectively increase the electrical signal. Additionally, the introduction of Gra significantly increased the loading amount of electroactive probes (Cu(I)/Cu(II)), and the electrical signal was further amplified. Cu(I)/Cu(II) and Cu(I)/Cu(II)-Chi-Gra were compared in detail to characterize the signal amplification ability of this platform. The results showed that this immunosensor exhibited excellent analytical performance in the detection of NDV in the concentration range of 10
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