Evidence map›Paper›PMID 32807821›Full record

ArticleScientific reports2020

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD

Sandra Cunha Silveira, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. 1,25-Dihydroxyvitamin DInternational journal of molecular sciences · 2024
    Article
  2. Harnessing NADCurrent heart failure reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Sandra Cunha Silveira *Institut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Géraldine Buhagiar-Labarchède *Institut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Rosine Onclercq-Delic *Institut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Simon GembleInstitut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Elias Bou SamraInstitut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Hamza MameriInstitut Curie, UMR 3348, PSL Research University, 91405, Orsay, France.
Patricia DuchambonProtein Expression and Purification Core Facility, Institut Curie, PSL Research University, 75248, Paris, France.
Christelle MachonLaboratoire de Biochimie et Toxicologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Jérôme GuittonLaboratoire de Biochimie et Toxicologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Mounira Amor-GuéretInstitut Curie, UMR 3348, PSL Research University, 91405, Orsay, France. mounira.amor@curie.fr.
Centre National de la Recherche Scientifique · FRInstitut Curie · FRUniversité Paris Sciences et Lettres · FRHôpital Lyon Sud · FRHospices Civils de Lyon · FRInserm · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge (UFB) formation. Here, we investigated the mechanism underlying the decrease in PARP-1 activity in CDA-deficient cells. PARP-1 activity is dependent on intracellular NAD

Indexed as

Cytidine DeaminaseCytokinesHeLa CellsHumansMutationNADNiacinamideNicotinamide PhosphoribosyltransferasePoly (ADP-Ribose) Polymerase-1Cytidine DeaminaseCytokinesNADNiacinamideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1

Identifiers

PMID32807821
PMCPMC7431583
OpenAlexW3049169282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.