ArticleScientific reports2020
Actinobacteria from Antarctica as a source for anticancer discovery.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Polytrichastrum alpinum methanol extract induces cell cycle arrest and apoptosis in mammary tumor cells of companion dogs.Genes & genomics · 2026Article
- Kineochelins-A New Group of Siderophores From an Antarctic Bacterium.Microbial biotechnology · 2026Article
- Site-specific community structure and plant growth-promoting properties of cultured actinomycetes associated with Deschampsia antarctica from Galindez Island, Antarctica.Folia microbiologica · 2026Article
- Exploring the molecular landscape of environmental responses in the Antarctic plantFrontiers in plant science · 2026Article
- Novel Antimicrobial Activities of Albofungin, Albonoursin, and Ribonucleosides Produced byMolecules (Basel, Switzerland) · 2025Article
- Recovery of 1,773 microbial genomes and 2,060 viral genomes from the Mars-analog Qaidam Basin desert.Scientific data · 2025Article
- Multi-omics analysis reveals intratumoral microbiota as modulators of the immune environment within thyroid cancer.Translational cancer research · 2025Article
- Why Do FilamentousAnnual review of microbiology · 2025Review
- Characterization of Mycobacterium antarcticum sp. nov., a psychrotolerant member of the genus Mycobacterium isolated from Antarctic soil.Scientific reports · 2025Article
- Antimicrobial potential of actinomycetes from high altitude Nepalese soils.Scientific reports · 2025Article
- Assessing the effect of temperature onMicrobiology (Reading, England) · 2025Article
- Intrathalline Fungal and Bacterial Diversity Is Uncovered in Antarctic Lichen Symbioses.Environmental microbiology reports · 2025Article
- Structural Characterisation of TetR/AcrR Regulators inInternational journal of molecular sciences · 2025Article
- Special Issue "Antifungal Drug Discovery: Progresses, Challenges, Opportunities".International journal of molecular sciences · 2025Article
- Article
- Biological activity of secondary metabolites of actinomycetes and their potential sources as antineoplastic drugs: a review.Frontiers in microbiology · 2025Review
- A multi-omics reciprocal analysis for characterization of bacterial metabolism.Frontiers in molecular biosciences · 2025Article
- Enhancing Antifungal Drug Discovery Through Co-Culture with AntarcticInternational journal of molecular sciences · 2024Article
- Harnessing bacterial metabolites for enhanced cancer chemotherapy: unveiling unique therapeutic potentials.Archives of microbiology · 2024Review
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC
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