ArticleTranslational psychiatry2020
The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gut microbiome differences in individuals with PTSD compared to trauma-exposed controls: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Early biological and psychosocial factors associated with PTSD onset and persistence in youth.European journal of psychotraumatology · 2024Pooled it
- A history of chronic adolescent stress attenuates cued fear-potentiated startle in adult female Wistar rats.Psychopharmacology · 2026Article
- PTSD symptoms, loneliness, and amygdala volumes during pandemic social distancing associated with risk of suicidal ideation in trauma survivors with and without pre-pandemic PTSD.Journal of affective disorders reports · 2026Article
- From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD.Journal of eating disorders · 2025Review
- The Role of Extracellular Vesicles in Neuropsychiatric Disorders.Advanced pharmaceutical bulletin · 2025Review
- Impact of Post-Traumatic Stress Disorder Duration on Volumetric and Microstructural Parameters of the Hippo-Campus, Amygdala, and Prefrontal Cortex: A Multiparametric Magnetic Resonance Imaging Study with Correlation Analysis.Journal of clinical medicine · 2025Article
- Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptoms.International journal of molecular sciences · 2025Review
- Neural correlates of concern about falling in multiple sclerosis: resting-state functional connectivity in amygdala-hippocampal and amygdala-cerebellar circuits.Experimental brain research · 2025Article
- State-dependent memory mechanisms insights from neural circuits and clinical implications.Frontiers in cellular neuroscience · 2025Review
- Neuroimaging in post-traumatic stress disorder: a narrative review.Archives of medical science : AMS · 2025Article
- Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.Frontiers in neuroscience · 2024Review
- Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review.Biological psychiatry global open science · 2024Article
- Neuroanatomical and functional correlates in post-traumatic stress disorder: A narrative review.Ibrain · 2024Review
- Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions - a review.Frontiers in psychiatry · 2024Review
- In vivo structural analyses of amygdala subregions in relation to stressful life events: A systematic review.Neuroscience applied · 2024Review
- Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders.Genes · 2023Review
- Neurologic Injury-Related Predisposing Factors of Post-Traumatic Stress Disorder: A Critical Examination.Biomedicines · 2023Review
- Reorganization in the macaque interoceptive-allostatic network following anterior cingulate cortex damage.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following traumatic stress exposure and in PTSD, the findings regarding amygdala volume have been mixed. One reason for these mixed findings may be that the amygdala has been considered as a homogenous entity, while it in fact consists of several nuclei with unique cellular and connectivity profiles. Here, we investigated amygdala nuclei volumes of the basolateral and the centrocorticomedial complex in relation to PTSD symptom severity in 47 young survivors from the 2011 Norwegian terror attack 24-36 months post-trauma. PTSD symptoms were assessed 4-5, 14-15 and 24-36 months following the trauma. We found that increased PTSD symptom severity 24-36 months post-trauma was associated with volumetric reductions of all basolateral as well as the central and the medial nuclei. However, only the lateral nucleus was associated with longitudinal symptom development, and mediated the association between 4-5 months and 24-36 months post-trauma symptoms. The results suggest that the amygdala nuclei may be differentially associated with cross-sectional and longitudinal measures of PTSD symptom severity. As such, investigations of amygdala total volume may not provide an adequate index of the association between amygdala and stress-related mental illness.
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