ArticleAmerican journal of surgery2020
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
Article in American journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Sepsis accelerates frailty and functional decline in older adults: a 12-month prospective study.Internal and emergency medicine · 2026Article
- Source-controlled bacterial peritonitis improves survival but leaves persistent lung inflammation and airway IgA loss.Intensive care medicine experimental · 2026Article
- Development and Validation of a Nomogram for Mortality Prediction in Septic Patients with Prolonged or Chronic Critical Illness.Diagnostics (Basel, Switzerland) · 2026Article
- Machine learning-based risk prediction of 28-day mortality for sepsis patients with augmented renal clearance.Scientific reports · 2026Article
- [Chronic Critical Illness in Burns: Incidence and Risk Factors].Annals of burns and fire disasters · 2025Article
- The Neurological Metabolic Phenotype in Prolonged/Chronic Critical Illness: Propensity Score Matched Analysis of Nutrition and Outcomes.Nutrients · 2025Article
- Prognostic impact of hypernatremia for septic shock patients in the intensive care unit.World journal of clinical cases · 2025Article
- Clinical characteristics and risk factors of chronic critical illness in children with sepsis.Frontiers in pediatrics · 2025Article
- Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.Critical care (London, England) · 2024Article
- Usefulness of laparoscopic surgery for colorectal perforation: a single-center retrospective cohort study.Surgery today · 2024Article
- The obesity paradox and 90 day mortality in chronic critically ill patients: a cohort study using a large clinical database.European journal of medical research · 2024Article
- The Tri-Steps Model of Critical Conditions in Intensive Care: Introducing a New Paradigm for Chronic Critical Illness.Journal of clinical medicine · 2024Article
- Reduced preoperative serum choline esterase levels and fecal peritoneal contamination as potential predictors for the leakage of intestinal sutures after source control in secondary peritonitis.World journal of emergency surgery : WJES · 2024Article
- Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.JCI insight · 2024Article
- Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness.Frontiers in immunology · 2024Article
- Surviving septic patients endotyped with a functional assay demonstrate active immune responses.Frontiers in immunology · 2024Observational
- Epigenome-wide DNA methylation profiling in septic and non-septic patients with similar infections: potential use as sepsis biomarkers.Frontiers in cellular and infection microbiology · 2024Article
- Article
- The association between culture positivity and long-term mortality in critically ill surgical patients.Journal of intensive care · 2021Article
- WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections.World journal of emergency surgery : WJES · 2021Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAs hospital sepsis mortality has decreased, more surgical ICU survivors are progressing into chronic critical illness (CCI). This study documents the incidence of CCI and long-term outcomes of patients with abdominal sepsis. We hypothesized that patients developing CCI would have biomarker evidence of immune and metabolic derangement, with a high incidence of poor 1-year outcomes.
methodsReview of abdominal sepsis patients entered in a prospective longitudinal study of surgical ICU sepsis.
resultsOf the 144 study patients, only 6% died early, 37% developed CCI (defined as ICU days ≥14 with organ dysfunction) and 57% were classified rapid recovery (RAP). Compared to RAP, CCI patients a) were older (66 vs 58), males who were sicker at baseline (Charlson Comorbidity Index 4 vs 2), b) had persistently elevated biomarkers of dysregulated immunity/metabolism (IL-6, IL-8, sPDL-1, GLP1), c) experienced more secondary infections (4.9 vs 2.3) and organ failure (Denver MOF frequency 40 vs 1%), d) were much more likely to have poor dispositions (85 vs 22%) with severe persistent disabilities by Zubrod Score and e) had a notably higher 1-year mortality of 42% (all p < 0.05).
conclusionOver 1/3rd surgical ICU patients treated for abdominal sepsis progress into CCI and experience dismal long-term outcomes.
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