ArticleCardiovascular diabetology2020
Pericardial fat and its influence on cardiac diastolic function.
Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01671930 (Maastricht Biomarker CT Study. Relation Between Cardiovascular Biomarkers and Coronary Atherosclerosis in Patients Undergoing Multi Detector Cardiac Computed Tomography.), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maastricht Biomarker CT Study. Relation Between Cardiovascular Biomarkers and Coronary Atherosclerosis in Patients Undergoing Multi Detector Cardiac Computed Tomography.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis.Journal of the American Heart Association · 2025Trial
- A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study.Cardiovascular diabetology · 2021Trial
- Epicardial Adipose Tissue in Diabetic Heart Disease: Impact on Cardiac Function and Modulation Strategies, a Comprehensive Review.Medicina (Kaunas, Lithuania) · 2026Review
- Pericardial Fat Radiomics to Predict Left Ventricular Involvement and Provide Incremental Prognostic Value in ARVC.Diagnostics (Basel, Switzerland) · 2025Article
- Time course of cardiovascular responses to acute sustained handgrip exercise in young physically active men.Physiological reports · 2025Article
- Association of Body Mass Index with Echocardiographic Parameters and Incidence of Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular Atrial Fibrillation: A Cross-Sectional Study.Reviews in cardiovascular medicine · 2025Article
- Epicardial adipose tissue volume highly correlates with left ventricular diastolic dysfunction in endogenous Cushing's syndrome.Annals of medicine · 2024Article
- Obesity cardiomyopathy could contribute to sudden cardiac death: a Japanese epidemiological morphological study.Cardiovascular diabetology · 2024Article
- Impact of epicardial adipose tissue on cardiac function and morphology in patients with diastolic dysfunction.ESC heart failure · 2024Article
- Correction to: Pericardial fat and its influence on cardiac diastolic function.Cardiovascular diabetology · 2024Article
- Correlation between clinical characteristics and epicardial adipose tissue features in acute myocarditis patients using coronary computed tomography (CT) vascular imaging: a case-control study with retrospective data collection.Quantitative imaging in medicine and surgery · 2024Article
- The Influence of Pericardial Fat on Left Ventricular Diastolic Function.Diagnostics (Basel, Switzerland) · 2024Article
- The correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function.BMC cardiovascular disorders · 2022Article
- Article
- Measurement of epicardial adipose tissue using non-contrast routine chest-CT: a consideration of threshold adjustment for fatty attenuation.BMC medical imaging · 2022Article
- Left ventricular diastolic function worsens over time in the setting of myocardial steatosis.The international journal of cardiovascular imaging · 2022Article
- Longitudinal effect of myocardial fat deposition on left ventricular diastolic function: a retrospective cohort study.The international journal of cardiovascular imaging · 2022Article
- Influence of Obesity on Histological Tissue Structure of the Cardiovascular System in Horses.Animals : an open access journal from MDPI · 2022Article
- Changes in Cardiac Metabolism in Prediabetes.Biomolecules · 2021Review
- Cardiac Adiposity and Arrhythmias: The Role of Imaging.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diastolic function in healthy subjects.
methods254 adults (40-70 years, BMI 18-35 kg/m
resultsSignificant associations for all four diastolic parameters with the PF volume were found after adjusting for BMI, age, and sex. In addition, subjects with high pericardial fat had a reduced left atrial volume index (p = 0.02), lower E/e (p < 0.01) and E/A (p = 0.01), reduced e' lateral (p < 0.01), reduced e' septal p = 0.03), compared to subjects with low pericardial fat.
conclusionThese findings confirm that pericardial fat volume, even in healthy subjects with normal cardiac function, is associated with diastolic function. Our results suggest that the mechanical effects of PF may limit the distensibility of the heart and thereby directly contribute to diastolic dysfunction. Trial registration NCT01671930.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.