Evidence map›Paper›PMID 32807165›Full record

Trial reportRespiratory research2020

Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial.

Afsane Ahmadi, Mohammad Hassan Eftekhari, Zohreh Mazloom, Masoom Masoompour, Mohammad Fararooei, Mohammad Hadi Eskandari, Samrad Mehrabi, Alireza Bedeltavana, Mandana Famouri, Morteza Zare and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Afsane AhmadiResearch Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hassan EftekhariDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. h_eftekhari@yahoo.com.
Zohreh MazloomDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoom MasoompourNon-communicable Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad FararooeiDepartment of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hadi EskandariDepartment of Food Sciences and Technology, School of Agriculture, Shiraz University, Shiraz, Iran.
Samrad MehrabiDepartment of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza BedeltavanaDairy Expert at Research and Development of Zarrin Ghazal Company (DAITY), Shiraz, Iran.
Mandana FamouriDairy Expert at Research and Development of Zarrin Ghazal Company (DAITY), Shiraz, Iran.
Morteza ZareNutrition Reasearch Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasrin NasimiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra SohrabiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRShiraz University · IR

Funding

Shiraz University of Medical Sciences 13723
6 · The paper itself

Abstract

backgroundThe development of effective nutritional supports for patients with chronic obstructive pulmonary diseases (COPD) is still challenging. This study was conducted to investigate the efficacy of daily consumption of fortified whey on inflammation, muscle mass, functionality, and quality of life in patients with moderate-to-severe COPD.

methodsA single-blind, randomized trial study was performed on patients with COPD (n = 46). Participants in the intervention group (n = 23) daily received 250 ml of whey beverage fortified with magnesium and vitamin C for 8 weeks. Any changes in inflammatory cytokines (including interleukin- 6 (IL-6) and tumor necrosis factor (TNFα)) were the primary outcomes and the secondary outcomes were fat-free mass, handgrip strength, malnutrition, glutathione and malondialdehyde serum concentrations, and health-related quality of life (HRQoL). Body composition and muscle strength were measured by Bioelectrical Impedance Analysis (BIA) and hydraulic hand dynamometer, respectively. Fat-free mass index (FFMI) was also calculated.

resultsAt the end of the study, 44 patients were analyzed. There were significant decreases in IL-6 concentrations in the intervention group compared to the control group. Also, FFMI, body protein, and handgrip strength increased significantly in the intervention group with significant changes between two groups. Moreover, improvement in health-related quality of life was observed in the intervention group compared to the control group. There were no significant changes in other study variables.

conclusionsThis novel nutritional intervention decreased inflammatory cytokines levels, improved indices of skeletal muscle mass and muscle strength, and ultimately, increased HRQoL in patients with moderate-to-severe COPD. Thus, it is suggested to do further studies to assess the effects of nutrition intervention on COPD progression.

trial registrationIR.SUMS.REC.1396.85 ( https://www.irct.ir/ ).

Indexed as

BeveragesFood, FortifiedAgedAscorbic AcidFemaleHand StrengthHumansMagnesiumMaleMiddle AgedMuscle, SkeletalMuscle StrengthPulmonary Disease, Chronic ObstructiveSingle-Blind MethodWheyAscorbic AcidMagnesiumCachexiaLung diseasesMagnesiumVitamin CWhey

Identifiers

PMID32807165
PMCPMC7430110
OpenAlexW3049559729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.