ArticleBMC microbiology2020
The gut mycobiota of rural and urban individuals is shaped by geography.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Clinical Significance of Intestinal Fungal Overgrowth: Integrating the Gut Mycobiome into Modern Gastroenterology.Microorganisms · 2026Review
- Gut Mycobiota Dysbiosis in People Living with HIV/AIDS: Insights from an Argentine Cohort with Severe Immunosuppression.Journal of fungi (Basel, Switzerland) · 2026Article
- Intestinal fungal dysbiosis in gestational diabetes mellitus is associated with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
- A Review of Global Patterns in Gut Microbiota Composition, Health and Disease: Locating South Africa in the Conversation.Microorganisms · 2025Review
- Dietary Effects, Age, and Urban-Rural Dynamics in Shaping Gut Microbiota of Elderly Vietnamese: A Cross-Sectional Study.Microorganisms · 2025Article
- Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates.PLoS biology · 2025Article
- Exploring the influence of urbanization on gut mycobiota through dietary habits in Burkina Faso.BMC microbiology · 2025Article
- The Human Mycobiome: Composition, Immune Interactions, and Impact on Disease.International journal of molecular sciences · 2025Review
- Double-Edged Sword: Urbanization and Response of Amniote Gut Microbiome in the Anthropocene.Microorganisms · 2025Review
- Gut microbiota profiles of peninsular Malaysian populations are associated with urbanization and lifestyle.Scientific reports · 2025Article
- Comparing the impact of landscape on the gut microbiome of Apis mellifera in Atlantic Forest and Caatinga Biomes.Scientific reports · 2025Article
- Multi-marker comparative analysis of 18S, ITS1, and ITS2 primers for human gut mycobiome profiling.Frontiers in bioinformatics · 2025Article
- Impact of urbanization on gut microbiome mosaics across geographic and dietary contexts.mSystems · 2024Article
- Neonatal Gut Mycobiome: Immunity, Diversity of Fungal Strains, and Individual and Non-Individual Factors.Life (Basel, Switzerland) · 2024Review
- African microbiomes matter.Nature reviews. Microbiology · 2023Article
- Fungal-Bacterial Interactions in the Human Gut of Healthy Individuals.Journal of fungi (Basel, Switzerland) · 2023Article
- Esophageal mycobiome landscape and interkingdom interactions in esophageal squamous cell carcinoma.Gastroenterology report · 2023Article
- The eukaryome of African children is influenced by geographic location, gut biogeography, and nutritional status.microLife · 2023Article
- The Human Mycobiome: Colonization, Composition and the Role in Health and Disease.Journal of fungi (Basel, Switzerland) · 2022Review
- Individuals with Inflammatory Bowel Disease Have an Altered Gut Microbiome Composition of Fungi and Protozoa.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the structure and drivers of gut microbiota remains a major ecological endeavour. Recent studies have shown that several factors including diet, lifestyle and geography may substantially shape the human gut microbiota. However, most of these studies have focused on the more abundant bacterial component and comparatively less is known regarding fungi in the human gut. This knowledge deficit is especially true for rural and urban African populations. Therefore, we assessed the structure and drivers of rural and urban gut mycobiota.
resultsOur participants (n = 100) were balanced by geography and sex. The mycobiota of these geographically separated cohorts was characterized using amplicon analysis of the Internal Transcribed Spacer (ITS) gene. We further assessed biomarker species specific to rural and urban cohorts. In addition to phyla which have been shown to be ubiquitous constituents of gut microbiota, Pichia were key constituents of the mycobiota. We found that geographic location was a major driver of gut mycobiota. Other factors such as smoking where also determined gut mycobiota albeit to a lower extent, as explained by the small proportion of total variation. Linear discriminant and the linear discriminant analysis effect size analysis revealed several distinct urban and rural biomarkers.
conclusionsTogether, our analysis reveals distinct community structure in urban and rural South African individuals. Geography was shown to be a key driver of rural and urban gut mycobiota.
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