ArticleBMC microbiology2020
Targeting the honey bee gut parasite Nosema ceranae with siRNA positively affects gut bacteria.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Wake Up and Smell the Infected Bees: Volatile Cues ofEcology and evolution · 2026Article
- The relationship between pollen monodiets and the activities of proteolytic systems in the fat body and hemolymph of honeybee workers.PloS one · 2025Article
- Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Probiotic candidates for controlling Paenibacillus larvae, a causative agent of American foulbrood disease in honey bee.BMC microbiology · 2023Article
- Isolation and characterization ofSaudi journal of biological sciences · 2023Article
- Effect of Nosema ceranae infection and season on the gut bacteriome composition of the European honeybee (Apis mellifera).Scientific reports · 2022Article
- CircRNA-regulated immune responses of asian honey bee workers to microsporidian infection.Frontiers in genetics · 2022Article
- Nosema apis and N. ceranae Infection in Honey bees: A Model for Host-Pathogen Interactions in Insects.Experientia supplementum (2012) · 2022Article
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- Extracts fromMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGut microbial communities can contribute positively and negatively to host health. So far, eight core bacterial taxonomic clusters have been reported in honey bees. These bacteria are involved in host metabolism and defenses. Nosema ceranae is a gut intracellular parasite of honey bees which destroys epithelial cells and gut tissue integrity. Studies have shown protective impacts of honey bee gut microbiota towards N. ceranae infection. However, the impacts of N. ceranae on the relative abundance of honey bee gut microbiota remains unclear, and has been confounded during prior infection assays which resulted in the co-inoculation of bacteria during Nosema challenges. We used a novel method, the suppression of N. ceranae with specific siRNAs, to measure the impacts of Nosema on the gut microbiome.
resultsSuppressing N. ceranae led to significant positive effects on microbial abundance. Nevertheless, 15 bacterial taxa, including three core taxa, were negatively correlated with N. ceranae levels. In particular, one co-regulated group of 7 bacteria was significantly negatively correlated with N. ceranae levels.
conclusionsN. ceranae are negatively correlated with the abundance of 15 identified bacteria. Our results provide insights into interactions between gut microbes and N. ceranae during infection.
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