ArticleCurrent neurovascular research2020
Stroke History is an Independent Risk Factor for Poor Prognosis in Ischemic Stroke Patients: Results from a Large Nationwide Stroke Registry.
Article in Current neurovascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combined exercise training to improve gait in older stroke patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Effects of an online stroke education program on enhancing knowledge, awareness of stroke warning signs, and emergency medical services seeking among high-risk residents in Huanggang City, China.Journal of education and health promotion · 2026Article
- Proinflammatory Risk Factors in Patients with Ischemic Stroke: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2025Review
- Risk factors and clinical significance of post-stroke incident ischemic lesions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Improving Stroke Outcome Prediction Using Molecular and Machine Learning Approaches in Large Vessel Occlusion.Journal of clinical medicine · 2024Article
- Interaction effect between blood selenium levels and stroke history on all-cause mortality: a retrospective cohort study of NHANES.Frontiers in neurology · 2024Article
- Ischaemic stroke despite antiplatelet therapy: Causes and outcomes.European stroke journal · 2023Article
- Age Stratification in Acute Ischemic Stroke Patients with Heart Failure.Journal of clinical medicine · 2022Article
- An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid.Frontiers in molecular biosciences · 2022Article
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7 authors.
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Abstract
backgroundThere is some controversy whether stroke history is an independent risk factor for poor prognosis of stroke or not. This study aimed to investigate the difference of mortality, disability and recurrent rate of ischemic stroke patients without and with stroke history, as well as to explore the effect of stroke history on stroke prognosis.
methodsWe analyzed patients with ischemic stroke enrolled in the China National Stroke Registry which was a nationwide, multicenter, and prospective registry of consecutive patients with acute cerebrovascular events from 2007 to 2008. Multivariable logistic regression was performed to assess the risk of worse prognosis of stroke history in patients with ischemic stroke.
resultsA total of 8181(65.9%) patients without stroke history and 4234(34.1%) patients with stroke history were enrolled in the study. The mortality, recurrence, modified Rankin Scale (mRS) 3-6 rate was 11.4%, 14.7% and 28.5% respectively at 1 year for patients without stroke history, which was significantly lower than that of 17.3%, 23.6%, 42.1% in patients with stroke history, respectively. Multivariable analysis showed that patients with stroke history had higher risk of death [odds ratio (OR) 1.34,95% confidence interval (CI) 1.17-1.54], recurrence (OR 1.47, 95 % CI 1.31-1.65) and mRS 3-6 (OR 1.49,95% CI 1.34-1.66) at 1 year.
conclusionAfter adjusting for the potential confounders, stroke history was still an independent risk factor for poor prognosis of ischemic stroke, which further emphasizes the importance of secondary prevention of ischemic stroke. The specific causes of poor prognosis in patients with history of stroke need to be furtherly investigated.
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