Evidence map›Paper›PMID 32807001›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington's disease.

Peter Klinkmueller, Martin Kronenbuerger, Xinyuan Miao, Jee Bang, Kia E Ultz, Adrian Paez, Xiaoyu Zhang, Wenzhen Duan, Russell L Margolis, Peter Cm van Zijl and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Peter KlinkmuellerDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
Martin KronenbuergerDivision of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xinyuan MiaoF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jee BangDivision of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kia E UltzDivision of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Adrian PaezF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Xiaoyu ZhangF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Wenzhen DuanDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Russell L MargolisDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter Cm van ZijlF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Christopher A RossDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jun HuaF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USKennedy Krieger Institute · US

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Huntington's Disease biomarkers and therapeuticsR01NS082338 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2013 to 2017
$2.0M
Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeuticsR56NS124084 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2021 to 2021
$522k
Imaging brain glucose uptake by onVDMP MRI in Huntington's DiseaseR21NS118079 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN, XU, JIADI · 2020 to 2020
$465k
Cerebrovascular Abnormalities in Huntington's DiseaseR21NS104480 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI DUAN, WENZHEN, HUA, JUN · 2018 to 2019
$446k
NIBIB NIH HHS P41 EB015909NINDS NIH HHS R01 NS082338NINDS NIH HHS R21 NS104480NINDS NIH HHS R21 NS118079NINDS NIH HHS R56 NS124084
6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG triplet repeat expansion in the Huntingtin gene. Metabolic and microvascular abnormalities in the brain may contribute to early physiological changes that subserve the functional impairments in HD. This study is intended to investigate potential abnormality in dynamic changes in cerebral blood volume (CBV) and cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO

Indexed as

AdultBiomarkersBrainBrain MappingCase-Control StudiesCerebral Blood VolumeCerebrovascular CirculationCross-Sectional StudiesEarly DiagnosisFemaleHumansHuntington DiseaseMagnetic Resonance ImagingMaleMiddle AgedNeurodegenerative DiseasesBiomarkersOxygenbiomarkerimagingneurodegenerationNeurovascularultra-high field

Identifiers

PMID32807001
PMCPMC8054727
OpenAlexW3063016744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.