Evidence map›Paper›PMID 32806768›Full record

ReviewCells2020

RNA-Binding Protein Rbm24 as a Multifaceted Post-Transcriptional Regulator of Embryonic Lineage Differentiation and Cellular Homeostasis.

Raphaëlle Grifone, Ming Shao, Audrey Saquet, De-Li Shi

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. RNA-Binding Proteins in Cardiomyopathies.Journal of cardiovascular development and disease · 2024
    Review
  9. Hypertrophic cardiomyopathy inThe journal of cardiovascular aging · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
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  15. Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Raphaëlle GrifoneDevelopmental Biology Laboratory, CNRS-UMR7622, IBPS, Sorbonne University, 75005 Paris, France.
Ming ShaoShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, China.
Audrey SaquetDevelopmental Biology Laboratory, CNRS-UMR7622, IBPS, Sorbonne University, 75005 Paris, France.
De-Li ShiDevelopmental Biology Laboratory, CNRS-UMR7622, IBPS, Sorbonne University, 75005 Paris, France.ORCID 0000-0002-6104-9137
Centre National de la Recherche Scientifique · FRShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are critically required for the post-transcriptional regulation of gene expression in a wide variety of physiological and pathological processes. Rbm24 is a highly conserved RNA-binding protein that displays strongly regionalized expression patterns and exhibits dynamic changes in subcellular localization during early development. There is increasing evidence that it acts as a multifunctional regulator to switch cell fate determination and to maintain tissue homeostasis. Dysfunction of Rbm24 disrupts cell differentiation in nearly every tissue where it is expressed, such as skeletal and cardiac muscles, and different head sensory organs, but the molecular events that are affected may vary in a tissue-specific, or even a stage-specific manner. Recent works using different animal models have uncovered multiple post-transcriptional regulatory mechanisms by which Rbm24 functions in key developmental processes. In particular, it represents a major splicing factor in muscle cell development, and plays an essential role in cytoplasmic polyadenylation during lens fiber cell terminal differentiation. Here we review the advances in understanding the implication of Rbm24 during development and disease, by focusing on its regulatory roles in physiological and pathological conditions.

Indexed as

Gene Expression RegulationAlternative SplicingAnimalsCell DifferentiationCell LineageCytoplasmEmbryonic DevelopmentHomeostasisHumansMuscle CellsPolyadenylationRNA-Binding ProteinsRBM24 protein, humanRNA-Binding Proteinsalternative splicingcell differentiationcytoplasmic polyadenylationhead sensory organinner earlensmuscleRbm24RNA-binding protein

Identifiers

PMID32806768
PMCPMC7463526
OpenAlexW3048640829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.