Evidence map›Paper›PMID 32806709›Full record

ArticleCells2020

Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium.

Francesca Balzano, Giuseppe Garroni, Sara Cruciani, Emanuela Bellu, Silvia Dei Giudici, Annalisa Oggiano, Giampiero Capobianco, Salvatore Dessole, Carlo Ventura, Margherita Maioli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. The Crucial Role of Epigenetic Modifications in Wharton's Jelly Stem Cells.International journal of molecular sciences · 2025
    Review
  3. Effects of the MCF-7 Exhausted Medium on hADSC Behaviour.International journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Role of miRNA-145, 148, and 185 and Stem Cells in Prostate Cancer.International journal of molecular sciences · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Francesca BalzanoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
Giuseppe GarroniDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
Emanuela BelluDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
Silvia Dei GiudiciIstituto Zooprofilattico Sperimentale della Sardegna, Via Vienna 2, 07100 Sassari, Italy.
Annalisa OggianoIstituto Zooprofilattico Sperimentale della Sardegna, Via Vienna 2, 07100 Sassari, Italy.
Giampiero CapobiancoDepartment of Medical, Surgical and experimental Sciences, Gynecologic and Obstetric Clinic, University of Sassari, 07100 Sassari, Italy.
Salvatore DessoleDepartment of Medical, Surgical and experimental Sciences, Gynecologic and Obstetric Clinic, University of Sassari, 07100 Sassari, Italy.
Carlo VenturaNational Laboratory of Molecular Biology and Stem Cell Bioengineering of the National Institute of Biostructures and Biosystems (NIBB)-Eldor Lab, at the Innovation Accelerator, CNR, Via Piero Gobetti 101, 40129 Bologna, Italy.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
University of Sassari · ITIstituto Zooprofilattico Sperimentale della Sardegna · ITIstituto Nazionale Biostrutture e Biosistemi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wharton jelly mesenchymal stem cells (WJ-MSCs) are able to differentiate into different cell lineages upon stimulation. This ability is closely related to the perfect balance between the pluripotency-related genes, which control stem-cell proliferation, and genes able to orchestrate the appearance of a specific phenotype. Here we studied the expression of stemness-related genes, epigenetic regulators (

Indexed as

PhenotypeCell Culture TechniquesCell DifferentiationCellular SenescenceCulture Media, ConditionedCyclin-Dependent Kinase Inhibitor p21DNA (Cytosine-5-)-Methyltransferase 1Gene Expression Regulation, NeoplasticHep G2 CellsHumansMesenchymal Stem CellsMicroRNAsOctamer Transcription Factor-3Proto-Oncogene Proteins c-mycSirtuin 1Wharton JellyCDKN1A protein, humanCulture Media, ConditionedCyclin-Dependent Kinase Inhibitor p21DNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanMicroRNAsMYC protein, humanOctamer Transcription Factor-3POU5F1 protein, humanProto-Oncogene Proteins c-mycSIRT1 protein, humanSirtuin 1cellular mechanismsexosomesmiRNAstem cell differentiation and proliferationstem cellsstemness genes

Identifiers

PMID32806709
PMCPMC7547384
OpenAlexW3048922721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.