Evidence map›Paper›PMID 32806704›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Copper Kills

Paula Maria Moreira Martins, Ting Gong, Alessandra A de Souza, Thomas K Wood

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. TheGenes · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Experimental Evolution of Copper Resistance inAntibiotics (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paula Maria Moreira MartinsDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Ting GongDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Alessandra A de SouzaBiotechnology Lab, Centro de Citricultura Sylvio Moreira, Instituto Agronômico de Campinas, Cordeirópolis-SP 13490-970, Brazil.
Thomas K WoodDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-6258-529X

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/18550-0
6 · The paper itself

Abstract

Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent manner. Some anti-persister compounds have been found previously, such as the DNA-crosslinkers mitomycin C and cisplatin, but more effective and lower cost alternatives are needed. Copper alloys have been used since ancient times due to their antimicrobial properties, and they are still used in agriculture to control plant bacterial diseases. By stopping transcription with rifampicin and by treating with ampicillin to remove non-persister cells, we created a population that consists solely of

Indexed as

copperpersisterVBNC

Identifiers

PMID32806704
PMCPMC7459663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.