Evidence map›Paper›PMID 32806654›Full record

ArticleMarine drugs2020

α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in

Yanli Liu, Yifeng Yin, Yunyang Song, Kang Wang, Fanghui Wu, Hui Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanli LiuState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Yifeng YinState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Yunyang SongState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Kang WangState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Fanghui WuState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Hui JiangState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α7 nicotinic acetylcholine receptors (nAChR) is an important nicotinic acetylcholine receptors subtype and closely associated with cognitive disorders, such as Alzheimer's and schizophrenia disease. The mutant ArIB (V11L, V16A) of α-conotoxin ArIB with 17-amino acid residues specifically targets α7 nAChR with no obvious effect on other nAChR subtypes. In the study, the synthetic gene encoding mature peptide of ArIB and mutant ArIB (V11L, V16A) carried a fusion protein Trx and 6 × His-tag was separately inserted in pET-32a (+) vector and transformed into

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsConotoxinsDose-Response Relationship, DrugEscherichia coliHistidineMembrane PotentialsNicotinic AntagonistsOligopeptidesOocytesRecombinant Fusion ProteinsThioredoxinsXenopus laevisalpha7 Nicotinic Acetylcholine ReceptorChrna7 protein, humanConotoxinsHistidineNicotinic AntagonistsOligopeptidesRecombinant Fusion ProteinsThioredoxinselectrophysiologyrecombinant expressionV16A)α7 nAChRα-conotoxin ArIB (V11L

Identifiers

PMID32806654
PMCPMC7460214
OpenAlexW3048798203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.