Evidence map›Paper›PMID 32806615›Full record

ReviewAnimals : an open access journal from MDPI2020

Overview of Quantitative Methodologies to Understand Antimicrobial Resistance via Minimum Inhibitory Concentration.

Alec Michael, Todd Kelman, Maurice Pitesky

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Designing of a novel chimeric antimicrobial peptide againstResearch in pharmaceutical sciences · 2025
    Article
  4. Prevalence of Variant GTRAntibiotics (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Antimicrobial Activity ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Surveillance of Antimicrobial Resistance ofAnimals : an open access journal from MDPI · 2024
    Article
  8. Antibiotics (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Serotype distribution and antibiogram ofMicrobiology spectrum · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Antimicrobial Resistance Profiles and Genes inFrontiers in veterinary science · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alec MichaelDepartment of Population Health and Reproduction, School of Veterinary Medicine, UC Davis, 1089 Veterinary Medicine Dr., VM3B, Davis, CA 95616, USA.ORCID 0000-0001-8651-5854
Todd KelmanDepartment of Population Health and Reproduction, School of Veterinary Medicine, UC Davis, 1089 Veterinary Medicine Dr., VM3B, Davis, CA 95616, USA.ORCID 0000-0002-9471-9299
Maurice PiteskyDepartment of Population Health and Reproduction, School of Veterinary Medicine-Cooperative Extension, UC Davis, 1089 Veterinary Medicine Dr., VM3B, Davis, CA 95616, USA.ORCID 0000-0003-0084-6404

Funding

California Department of Food and Agriculture 17-0242
6 · The paper itself

Abstract

The development of antimicrobial resistance (AMR) represents a significant threat to humans and food animals. The use of antimicrobials in human and veterinary medicine may select for resistant bacteria, resulting in increased levels of AMR in these populations. As the threat presented by AMR increases, it becomes critically important to find methods for effectively interpreting minimum inhibitory concentration (MIC) tests. Currently, a wide array of techniques for analyzing these data can be found in the literature, but few guidelines for choosing among them exist. Here, we examine several quantitative techniques for analyzing the results of MIC tests and discuss and summarize various ways to model MIC data. The goal of this review is to propose important considerations for appropriate model selection given the purpose and context of the study. Approaches reviewed include mixture models, logistic regression, cumulative logistic regression, and accelerated failure time-frailty models. Important considerations in model selection include the objective of the study (e.g., modeling MIC creep vs. clinical resistance), degree of censoring in the data (e.g., heavily left/right censored vs. primarily interval censored), and consistency of testing parameters (e.g., same range of concentrations tested for a given antibiotic).

Indexed as

accelerated failure time-frailty modelsAMRcumulative logistic regressionlogistic regressionMICmixed effect modelsmixture models

Identifiers

PMID32806615
PMCPMC7459578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.