ReviewDiagnostics (Basel, Switzerland)2020
A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases-Actual Applications and Future Perspectives.
Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06826638 (Investigate Neuro-rehabilitation Active Ingredients of Specific Task-oriented Training In People With Multiple Sclerosis With Different Challenging Conditions and Extrinsic Feedbacks), which is not on this map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigate Neuro-rehabilitation Active Ingredients of Specific Task-oriented Training In People With Multiple Sclerosis With Different Challenging Conditions and Extrinsic Feedbacks
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- fNIRS in Emotional Appraisal and the Dorsolateral Prefrontal Cortex: A Systematic Review.Revista de neurologia · 2025Pooled it
- Alterations in brain functional connectivity in patients with mild cognitive impairment: A systematic review and meta-analysis of functional near-infrared spectroscopy studies.Brain and behavior · 2024Pooled it
- Frontiers and hotspots evolution in mild cognitive impairment: a bibliometric analysis of from 2013 to 2023.Frontiers in neuroscience · 2024Pooled it
- Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review.Frontiers in physiology · 2023Pooled it
- Clinical Utility of Functional Near-Infrared Spectroscopy for Assessment and Prediction of Suicidality: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Accuracy deficits during robotic time-constrained reaching are related to altered prefrontal cortex activity in children with cerebral palsy.Journal of neuroengineering and rehabilitation · 2024Trial
- Screening diagnosis of executive dysfunction after ischemic stroke and the effects of transcranial magnetic stimulation: A prospective functional near-infrared spectroscopy study.CNS neuroscience & therapeutics · 2023Trial
- Electroencephalography-Based Brain-Computer Interface System Using Tongue Movement Imagery for Wheelchair Control.Sensors (Basel, Switzerland) · 2026Article
- Neurovascular Coupling: Scientometric Analysis of 30 Years Research (1996-2025).Brain and behavior · 2025Article
- Effective Functional Pattern Between Prefrontal fNIRS Activity and Cognitive Performance in Patients With Parkinson's Disease: A Data-Driven PLS Approach.Brain and behavior · 2025Article
- Direct 3-D printing of complex optical phantoms using dynamic filament mixing.Scientific reports · 2025Article
- Functional near-infrared spectroscopy and vagus somatosensory evoked potentials add to the power of established parameters such as poor cognitive performance, dsyosmia and APOe genotype to predict cognitive decline over 8 years in the elderly.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Creating anatomically derived, standardized, customizable, and three-dimensional printable head caps for functional neuroimaging.Neurophotonics · 2025Article
- Effect of canalith repositioning on resting-state brain functional connectivity in patients with benign paroxysmal positional vertigo.Frontiers in neurology · 2025Article
- Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice.Frontiers in bioengineering and biotechnology · 2025Article
- A compact time-domain diffuse optical tomography system for cortical neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Creating anatomically-derived, standardized, customizable, and three-dimensional printable head caps for functional neuroimaging.bioRxiv : the preprint server for biology · 2024Article
- Fabrication of complex optical phantoms using on-the-fly multi-filament mixing 3-D printing.Research square · 2024Article
- Decreased resting-state functional connectivity and brain network abnormalities in the prefrontal cortex of elderly patients with Parkinson's disease accompanied by depressive symptoms.Global health & medicine · 2024Article
- Beta-Gamma Phase-Amplitude Coupling as a Non-Invasive Biomarker for Parkinson's Disease: Insights from Electroencephalography Studies.Life (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of people affected by age-related neurological disorders requires the adoption of targeted and cost-effective interventions to cope with chronicity. Therapy adaptation and rehabilitation represent major targets requiring long-term follow-up of neurodegeneration or, conversely, the promotion of neuroplasticity mechanisms. However, affordable and reliable neurophysiological correlates of cerebral activity to be used throughout treatment stages are often lacking. The aim of this systematic review is to highlight actual applications of functional Near-Infrared Spectroscopy (fNIRS) as a versatile optical neuroimaging technology for investigating cortical hemodynamic activity in the most common chronic neurological conditions.
methodsWe reviewed studies investigating fNIRS applications in Parkinson's Disease (PD), Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) as those focusing on motor and cognitive impairment in ageing and Multiple Sclerosis (MS) as the most common chronic neurological disease in young adults. The literature search was conducted on NCBI PubMed and Web of Science databases by PRISMA guidelines.
resultsWe identified a total of 63 peer-reviewed articles. The AD spectrum is the most investigated pathology with 40 articles ranging from the traditional monitoring of tissue oxygenation to the analysis of functional resting-state conditions or cognitive functions by means of memory and verbal fluency tasks. Conversely, applications in PD (12 articles) and MS (11 articles) are mainly focused on the characterization of motor functions and their association with dual-task conditions. The most investigated cortical area is the prefrontal cortex, since reported to play an important role in age-related compensatory mechanism and neurofunctional changes associated to these chronic neurological conditions. Interestingly, only 9 articles applied a longitudinal approach.
conclusionThe results indicate that fNIRS is mainly employed for the cross-sectional characterization of the clinical phenotypes of these pathologies, whereas data on its utility for longitudinal monitoring as surrogate biomarkers of disease progression and rehabilitation effects are promising but still lacking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.