ArticleACS nano2020
Collagen-Inspired Helical Peptide Coassembly Forms a Rigid Hydrogel with Twisted Polyproline II Architecture.
Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Synergistic Multicomponent Nucleopeptide-Based Hydrogels: Harnessing DNA-Base Pairing and Electrostatic Complementarities.ACS materials Au · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Assessment of Bovine Collagen Manufactured via Cellular Agriculture.ACS biomaterials science & engineering · 2026Article
- Fine Tuning of Tyrosine-Derived Amphiphilic and Bolaamphiphilic Gelators for the Formation of pH-Responsive Supramolecular Gels.Precision chemistry · 2026Article
- Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment.Journal of nanobiotechnology · 2025Article
- Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing.ACS applied materials & interfaces · 2025Article
- Effects of proline substitution/inclusion on the nanostructure of a self-assembling β-sheet-forming peptide.RSC advances · 2024Article
- A Matter of Charge: Electrostatically Tuned Coassembly of Amphiphilic Peptides.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Enhancement of Collagen-I Levels in Human Gingival Fibroblasts by Small Molecule Activation of HIF-1α.Journal of agricultural and food chemistry · 2023Article
- Molecular Engineering of Rigid Hydrogels Co-assembled from Collagenous Helical Peptides Based on a Single Triplet Motif.ACS applied materials & interfaces · 2022Article
- Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Effects of a Short Self-Assembling Peptide on the Physical and Biological Properties of Biopolymer Hydrogels.Pharmaceutics · 2021Article
- Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin.International journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen, the most abundant protein in mammals, possesses notable cohesion and elasticity properties and efficiently induces tissue regeneration. The Gly-Pro-Hyp canonical tripeptide repeating unit of the collagen superhelix has been well-characterized. However, to date, the shortest tripeptide repeat demonstrated to attain a helical conformation contained 3-10 peptide repeats. Here, taking a minimalistic approach, we studied a single repeating unit of collagen in its protected form, Fmoc-Gly-Pro-Hyp. The peptide formed single crystals displaying left-handed polyproline II superhelical packing, as in the native collagen single strand. The crystalline assemblies also display head-to-tail H-bond interactions and an "aromatic zipper" arrangement at the molecular interface. The coassembly of this tripeptide, with Fmoc-Phe-Phe, a well-studied dipeptide hydrogelator, produced twisted helical fibrils with a polyproline II conformation and improved hydrogel mechanical rigidity. The design of these peptides illustrates the possibility to assemble superhelical nanostructures from minimal collagen-inspired peptides with their potential use as functional motifs to introduce a polyproline II conformation into hybrid hydrogel assemblies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.