Evidence map›Paper›PMID 32805967›Full record

ArticleACS applied materials & interfaces2020

Tuning Composition of Polymer and Porous Silicon Composite Nanoparticles for Early Endosome Escape of Anti-microRNA Peptide Nucleic Acids.

Isom B Kelly, R Brock Fletcher, James R McBride, Sharon M Weiss, Craig L Duvall

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. NonviralACS nano · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Multifunctional Delivery Systems for Peptide Nucleic Acids.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Isom B KellyDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
R Brock FletcherDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
James R McBrideVanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0003-0161-7283
Sharon M WeissDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0003-2252-3104
Craig L DuvallDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0003-3979-0620
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
MK2 Inhibitory Nanoplexes to Enhance Long-Term Vascular Graft PatencyR01HL122347 · NHLBI · VANDERBILT UNIVERSITY · PI DUVALL, CRAIG LEWIS · 2016 to 2020
$2.2M
NCI NIH HHS P30 CA068485NHLBI NIH HHS R01 HL122347
6 · The paper itself

Abstract

Porous silicon nanoparticles (PSNPs) offer tunable pore structure and easily modified surface chemistry, enabling high loading capacity for drugs with diverse chemicophysical properties. While PSNPs are also cytocompatible and degradable, PSNP integration into composite structures can be a useful approach to enhance carrier colloidal stability, drug-cargo loading stability, and endosome escape. Here, we explored PSNP polymer composites formed by coating of oxidized PSNPs with a series of poly[ethylene glycol-

Indexed as

Cell Line, TumorCell SurvivalEndosomesHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMicroRNAsNanoparticlesPeptide Nucleic AcidsPolymersPorosityRNA InterferenceSiliconMicroRNAsMIRN122 microRNA, humanPeptide Nucleic AcidsPolymersSiliconendosomal escapegalectin-8micro-RNApeptide nucleic acidporous silicon nanoparticles

Identifiers

PMID32805967
PMCPMC8356247
OpenAlexW3046261556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.