Evidence map›Paper›PMID 32805769›Full record

ArticleBrain pathology (Zurich, Switzerland)2021

TERT promoter mutations in primary and secondary WHO grade III meningioma.

Andrea Daniela Maier, Adam Stenman, Fredrika Svahn, Christian Mirian, Jiri Bartek, Marianne Juhler, Jan Zedenius, Helle Broholm, Tiit Mathiesen

Open access · hybridAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Loss of H3K27me3 in WHO grade 3 meningioma.Brain tumor pathology · 2022
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Andrea Daniela MaierDepartment of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-5930-0636
Adam StenmanDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Fredrika SvahnDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Christian MirianDepartment of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-6801-0123
Jiri BartekDepartment of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Marianne JuhlerDepartment of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jan ZedeniusDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Helle BroholmDepartment of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark.
Tiit MathiesenDepartment of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Copenhagen University Hospital · DKKarolinska University Hospital · SEKarolinska Institutet · SEUniversity of Copenhagen · DK

Funding

Kraeftens Bekaempelse R214-A12839
6 · The paper itself

Abstract

purposeTERT promoter mutation (TERTp

methodsWe gathered material from a consecutive single-center cohort of 40 patients with malignant meningioma (WHO grade III) treated between 2000 and 2018, including specimens from primary and secondary malignant meningiomas with the corresponding earlier benign specimens and later malignant recurrences. In total 107 tumor samples were studied by Sanger sequencing for TERT promoter mutational status.

resultsSeven of 40 patients (17.5%) harbored TERTp

conclusionTERTp

Indexed as

AdolescentAdultAgedAged, 80 and overChildCohort StudiesFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalPoint MutationPromoter Regions, GeneticTelomeraseTERT protein, humanmalignant meningiomamalignant progressionmeningiomaTERT promoter mutations

Identifiers

PMID32805769
PMCPMC8018144
OpenAlexW3080850798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.