Evidence map›Paper›PMID 32805729›Full record

ArticleAging2020

Radioprotectors.org: an open database of known and predicted radioprotectors.

Alexander M Aliper, Marine E Bozdaganyan, Viktoria A Sarkisova, Alexander P Veviorsky, Ivan V Ozerov, Philipp S Orekhov, Mikhail B Korzinkin, Alexey Moskalev, Alex Zhavoronkov, Andreyan N Osipov

Abstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. DAMPs and radiation injury.Frontiers in immunology · 2024
    Review
  11. Review
  12. Article
  13. An overview of radiation-induced heart disease.Radiation oncology journal · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander M AliperInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Marine E BozdaganyanInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Viktoria A SarkisovaInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Alexander P VeviorskyInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Ivan V OzerovInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Philipp S OrekhovInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Mikhail B KorzinkinInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Alexey MoskalevDepartment of Radioecology, Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology of the FRC of Komi Science Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
Alex ZhavoronkovInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Andreyan N OsipovInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for radioprotectors is an ambitious goal with many practical applications. Particularly, the improvement of human radioresistance for space is an important task, which comes into view with the recent successes in the space industry. Currently, all radioprotective drugs can be divided into two large groups differing in their effectiveness depending on the type of exposure. The first of these is radioprotectors, highly effective for pulsed, and some types of relatively short exposure to irradiation. The second group consists of long-acting radioprotectors. These drugs are effective for prolonged and fractionated irradiation. They also protect against impulse exposure to ionizing radiation, but to a lesser extent than short-acting radioprotectors. Creating a database on radioprotectors is a necessity dictated by the modern development of science and technology. We have created an open database, Radioprotectors.org, containing an up-to-date list of substances with proven radioprotective properties. All radioprotectors are annotated with relevant chemical and biological information, including transcriptomic data, and can be filtered according to their properties. Additionally, the performed transcriptomics analysis has revealed specific transcriptomic profiles of radioprotectors, which should facilitate the search for potent radioprotectors.

Indexed as

Databases, PharmaceuticalAccess to InformationAnimalsCellular SenescenceDNA DamageHumansInformation DisseminationRadiation ExposureRadiation InjuriesRadiation-Protective AgentsSkin AgingTranscriptomeRadiation-Protective Agentsantioxidantsfree radical scavengersionising radiationradiation mitigatorsradioprotectors

Identifiers

PMID32805729
PMCPMC7467366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.