Evidence map›Paper›PMID 32805188›Full record

ArticleJournal of the American Heart Association2020

Identification of Genes and Pathways Regulated by Lamin A in Heart.

Jordi Coste Pradas, Gaelle Auguste, Scot J Matkovich, Raffaella Lombardi, Suet Nee Chen, Tyrone Garnett, Kyle Chamberlain, Jalish Mahmud Riyad, Thomas Weber, Sanjay K Singh and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. An Epi(c) Path to LMNA Cardiomyopathy.JACC. Basic to translational science · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cardiac phenotypes in LMNA mutations.Current opinion in cardiology · 2025
    Review
  8. Cells · 2024
    Article
  9. Article
  10. Article
  11. Transcriptome studies of inherited dilated cardiomyopathies.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  12. Sinus node dysfunction: current understanding and future directions.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  13. Article
  14. Review
  15. Identification of Genes and Pathways Regulated by Lamin A in Heart.Journal of the American Heart Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jordi Coste PradasCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Gaelle AugusteCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Scot J MatkovichCenter for Cardiovascular Research St Louis MO.
Raffaella LombardiCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Suet Nee ChenCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Tyrone GarnettCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Kyle ChamberlainCardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Jalish Mahmud RiyadCardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Thomas WeberCardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Sanjay K SinghMD Anderson Cancer Center Houston TX.
Matthew J RobertsonBaylor College of Medicine Houston TX.
Cristian CoarfaBaylor College of Medicine Houston TX.
Ali J MarianCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
Priyatansh GurhaCenter for Cardiovascular Genetics Institute of Molecular Medicine University of Texas Health Sciences Center at Houston TX.
The University of Texas Health Science Center at Houston · USCardiovascular Institute of the South · USBaylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · US

Funding

Pathogenic Role of Selected Cardiac Myocyte- and Fibroblast-Specific Epigenetic Changes in LaminopathiesR01HL132401 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Ali J Marian · 2016 to 2026
$6.0M
Canonical Wnt Signaling in Pathogenesis and Rescue of ARVC PhenotypeR01HL088498 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARIAN, ALI J · 2008 to 2017
$3.4M
Pathogenic role of epigenetic regulator KDM5, a Histone H3 Lysine 4 demethylase in laminopathiesR21AG060413 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GURHA, PRIYATANSH · 2018 to 2019
$439k
NHLBI NIH HHS R01 HL088498NHLBI NIH HHS R01 HL132401NIA NIH HHS R21 AG060413
6 · The paper itself

Abstract

Background Mutations in the

Indexed as

Gene Expression RegulationRegulatory Elements, TranscriptionalAnimalsEpigenesis, GeneticLaminopathiesLamin Type AMiceMyocardiumPhenotypeRNA, Long NoncodingRNA, MessengerLamin Type ARNA, Long NoncodingRNA, MessengercardiomyopathiesKDM5laminopathiesLMNA

Identifiers

PMID32805188
PMCPMC7660829
OpenAlexW3046521009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.