ArticlePloS one2020
Learning machine approach reveals microbial signatures of diet and sex in dog.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The gut microbiota of Labrador retriever puppies: a longitudinal cohort study.Animal microbiome · 2025Article
- Nutritional and Microbiome Effects of a Partial Substitution of Poultry Meat with Hydrolyzed Feather Meal in Dog Diets.Microorganisms · 2025Article
- Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study.PloS one · 2025Article
- Evaluation of extended-spectrumFrontiers in microbiology · 2025Article
- Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations.Microorganisms · 2024Review
- Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes.Applied microbiology and biotechnology · 2024Article
- Species-level characterization of the core microbiome in healthy dogs using full-length 16S rRNA gene sequencing.Frontiers in veterinary science · 2024Article
- Analysis of the gut microbiome in sled dogs reveals glucosamine- and activity-related effects on gut microbial composition.Frontiers in veterinary science · 2024Article
- Characterization and Description of the Fecal Microbiomes of Pet Domestic Ferrets (Animals : an open access journal from MDPI · 2023Article
- Factors Affecting Gut Microbiota of Puppies from Birth to Weaning.Animals : an open access journal from MDPI · 2023Review
- Advances in machine learning-based bacteria analysis for forensic identification: identity, ethnicity, and site of occurrence.Frontiers in microbiology · 2023Review
- Alterations in Healthy Adult Canine Faecal Microbiome and Selected Metabolites as a Result of Feeding a Commercial Complete Synbiotic Diet withAnimals : an open access journal from MDPI · 2022Article
- Machine Learning and Canine Chronic Enteropathies: A New Approach to Investigate FMT Effects.Veterinary sciences · 2022Article
- Phenotypic correlates of the working dog microbiome.NPJ biofilms and microbiomes · 2022Article
- Geographically diverse canid sampling provides novel insights into pre-industrial microbiomes.Proceedings. Biological sciences · 2022Article
- Composition and short-term stability of gut microbiota in lean and spontaneously overweight healthy Labrador retriever dogs.Acta veterinaria Scandinavica · 2022Article
- Perspectives and advances in probiotics and the gut microbiome in companion animals.Journal of animal science and technology · 2022Review
- Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment.Animals : an open access journal from MDPI · 2021Article
- Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution.Animals : an open access journal from MDPI · 2021Article
- Best Practices for Microbiome Study Design in Companion Animal Research.Frontiers in veterinary science · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of the microbial population of many niches of the organism, as the gastrointestinal tract, is now possible thanks to the use of high-throughput DNA sequencing technique. Several studies in the companion animals field already investigated faecal microbiome in healthy or affected subjects, although the methodologies used in the different laboratories and the limited number of animals recruited in each experiment does not allow a straight comparison among published results. In the present study, we report data collected from several in house researches carried out in healthy dogs, with the aim to seek for a variability of microbial taxa in the faeces, caused by factors such as diet and sex. The database contains 340 samples from 132 dogs, collected serially during dietary intervention studies. The procedure of samples collection, storage, DNA extraction and sequencing, bioinformatic and statistical analysis followed a standardized pipeline. Microbial profiles of faecal samples have been analyzed applying dimensional reduction discriminant analysis followed by random forest analysis to the relative abundances of genera in the feces as variables. The results supported the responsiveness of microbiota at a genera taxonomic level to dietary factor and allowed to cluster dogs according this factor with high accuracy. Also sex factor clustered dogs, with castrated males and spayed females forming a separated group in comparison to intact dogs, strengthening the hypothesis of a bidirectional interaction between microbiota and endocrine status of the host. The findings of the present analysis are promising for a better comprehension of the mechanisms that regulate the connection of the microorganisms living the gastrointestinal tract with the diet and the host. This preliminary study deserves further investigation for the identification of the factors affecting faecal microbiome in dogs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.