Evidence map›Paper›PMID 32804569›Full record

ArticleCirculation2020

Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy.

Michael C Honigberg, Mark Chaffin, Krishna Aragam, Deepak L Bhatt, Malissa J Wood, Amy A Sarma, Nandita S Scott, Gina M Peloso, Pradeep Natarajan

Abstract readLetter
In one paragraph

Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Sex differences in coronary artery disease.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  5. Review
  6. Observational
  7. Review
  8. Preeclampsia and eclampsia: Enhanced detection and treatment for morbidity reduction.Best practice & research. Clinical anaesthesiology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Functional polymorphisms ofFrontiers in genetics · 2024
    Article
  14. Genetic contributions to risk of adverse pregnancy outcomes.Current cardiovascular risk reports · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael C HonigbergCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
Mark ChaffinProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (M.C.H., M.C., K.A., P.N.).
Krishna AragamCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
Deepak L BhattBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA (D.L.B.).
Malissa J WoodCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
Amy A SarmaCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
Nandita S ScottCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, MA (G.M.P.).
Pradeep NatarajanCardiology Division (M.C.H., K.A., M.J.W., A.A.S., N.S.S., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston.

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Whole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7M
NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Polymorphism, Single NucleotideAdultFemaleGenome-Wide Association StudyHumansPre-EclampsiaPregnancybody mass indexdiabetes mellitus, type 2genetic predisposition to diseasegenome-wide association studyhypertension, pregnancy-induced

Identifiers

PMID32804569
PMCPMC7436942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.