ArticleHuman brain mapping2020
Whole-brain functional connectivity correlates of obesity phenotypes.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Large-Scale Brain Network Connectivity Mediates the Association Between Metabolic Risk Factors and Cognition: An fMRI Study of the Human Connectome Project.International journal of endocrinology and metabolism · 2026Article
- Prior preferences interfere with the associative learning of food values.Communications psychology · 2026Article
- Brain functional connectivity patterns associated with adiposity in schizophrenia.Psychiatry research. Neuroimaging · 2026Article
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.Diabetes, obesity & metabolism · 2025Article
- Neural Correlates of Eating Habits and Nutritional Behaviors in the General Population: A Systematic Review of Observational Studies.Health science reports · 2025Review
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- A study on the brain mechanisms of postural control improvement in obese college students through traditional martial arts Tan Tui practice.Frontiers in psychology · 2025Article
- The macroscale routing mechanism of structural brain connectivity related to body mass index.Human brain mapping · 2024Article
- Obesity is associated with alterations in anatomical connectivity of frontal-corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Identifying subgroups of eating behavior traits unrelated to obesity using functional connectivity and feature representation learning.Human brain mapping · 2024Article
- Stress-induced brain responses are associated with BMI in women.Communications biology · 2023Article
- Multivariate resting-state functional connectomes predict and characterize obesity phenotypes.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Neuroanatomical correlates of genetic risk for obesity in children.Translational psychiatry · 2023Article
- The SACT Template: A Human Brain Diffusion Tensor Template for School-age Children.Neuroscience bulletin · 2022Article
- Disrupted stepwise functional brain organization in overweight individuals.Communications biology · 2022Article
- Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers.Frontiers in psychiatry · 2022Article
- Inter-individual body mass variations relate to fractionated functional brain hierarchies.Communications biology · 2021Article
- Whole-brain functional connectivity correlates of obesity phenotypes.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole-brain functional connectivity remains poorly understood. Here, we identified a neuroimaging-based functional connectivity pattern associated with obesity phenotypes by using functional connectivity analysis combined with machine learning in a large-scale (n ~ 2,400) dataset spanning four independent cohorts. We found that brain regions containing the reward circuit positively associated with obesity phenotypes, while brain regions for sensory processing showed negative associations. Our study introduces a novel perspective for understanding how the whole-brain functional connectivity correlates with obesity phenotypes. Furthermore, we demonstrated the generalizability of our findings by correlating the functional connectivity pattern with obesity phenotypes in three independent datasets containing subjects of multiple ages and ethnicities. Our findings suggest that obesity phenotypes can be understood in terms of macroscale whole-brain functional connectivity and have important implications for the obesity neuroimaging community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.