Evidence map›Paper›PMID 32804340›Full record

ArticleScience China. Life sciences2021

Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue.

Chenji Ye, Jinjie Duan, Xuejiao Zhang, Liu Yao, Yayue Song, Guangyan Wang, Qi Li, Biqing Wang, Ding Ai, Chunjiong Wang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Pulling the trigger: Noncoding RNAs in white adipose tissue browning.Reviews in endocrine & metabolic disorders · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. miR-429-3p/Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chenji YeTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Jinjie DuanTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Xuejiao ZhangTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Liu YaoTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Yayue SongTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Guangyan WangTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Qi LiTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Biqing WangTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Ding AiTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.
Chunjiong WangTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China. wangchunjiong@tmu.edu.cn.
Yi ZhuTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China. zhuyi@tmu.edu.cn.
Tianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases; yet the mechanisms are not fully understood. Yes-associated-protein (YAP), a transcription co-activator, was demonstrated to regulate adipose tissue functions; however, its effects on browning of subcutaneous white adipose tissue (sWAT) are unclear. We demonstrated that YAP was highly expressed in cold-induced beige fat. Mechanistically, YAP was found as a target gene of miR-429, which downregulated YAP expression

Indexed as

Cold Temperature3T3-L1 CellsAdipose Tissue, BeigeAdipose Tissue, WhiteAgingAnimalsHEK293 CellsHumansMaleMiceMice, Inbred C57BLMicroRNAsProtein DomainsTranscription, GeneticUncoupling Protein 1YAP-Signaling ProteinsMicroRNAsMIRN429 microRNA, mouseUcp1 protein, mouseUncoupling Protein 1YAP-Signaling ProteinsagingbrowningmiR-429UCP1YAP

Identifiers

PMID32804340
OpenAlexW3068639962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.