Evidence map›Paper›PMID 32804310›Full record

ArticleIntensive care medicine experimental2020

In vivo testing of the low-flow CO

Alexandra G May, Ryan A Orizondo, Brian J Frankowski, Sang-Ho Ye, Ergin Kocyildirim, William R Wagner, Jonathan D'Cunha, William J Federspiel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandra G MayDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA.
Ryan A OrizondoMcGowan Institute for Regenerative Medicine, University of Pittsburgh, 3025 East Carson Street, Pittsburgh, PA, 15203, USA.
Brian J FrankowskiMcGowan Institute for Regenerative Medicine, University of Pittsburgh, 3025 East Carson Street, Pittsburgh, PA, 15203, USA.
Sang-Ho YeMcGowan Institute for Regenerative Medicine, University of Pittsburgh, 3025 East Carson Street, Pittsburgh, PA, 15203, USA.
Ergin KocyildirimMcGowan Institute for Regenerative Medicine, University of Pittsburgh, 3025 East Carson Street, Pittsburgh, PA, 15203, USA.
William R WagnerDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA.
Jonathan D'CunhaDivision of Lung Transplantation/Lung Failure, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA.
William J FederspielDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA. wfedersp@pitt.edu.ORCID http://orcid.org/0000-0002-7068-6779

Funding

NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Paracorporeal Ambulatory Assist LungR01HL117637 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTAKI, JAMES F., DCUNHA, JONATHAN · 2013 to 2017
$3.5M
Ambulatory Assist Lung for ChildrenR01HL135482 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FEDERSPIEL, WILLIAM J., WAGNER, WILLIAM R · 2017 to 2020
$2.9M
NCATS NIH HHS TL1 TR001858NCATS NIH HHS TL1TR001858NHLBI NIH HHS R01 HL117637NHLBI NIH HHS R01HL117637NHLBI NIH HHS R01 HL135482NHLBI NIH HHS R01HL135482NHLBI NIH HHS T32 HL076124NIH HHS T32HL076124
6 · The paper itself

Abstract

backgroundNon-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by reducing airway pressures. These less invasive techniques can fail due to hypercapnia and require transitioning patients to invasive mechanical ventilation. Extracorporeal CO

methodsThe Modular Extracorporeal Lung Assist System was connected to 6 healthy sheep via a 15.5 Fr dual-lumen catheter placed in the external jugular vein. The animals were recovered and tethered within a pen while supported by the device for 7 days. The pump speed was set to achieve a targeted blood flow of 500 mL/min. The extracorporeal CO

resultsAll animals survived the surgery and generally tolerated the device well. One animal required early termination due to a pulmonary embolism. Intra-device thrombus formation occurred in a single animal due to improper anticoagulation. The average CO

conclusionThese in vivo results indicate positive performance of the Modular Extracorporeal Lung Assist System as a low-flow CO

Indexed as

Carbon dioxideExtracorporeal CO2 removalHypercapnia

Identifiers

PMID32804310
PMCPMC7429452

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.