Evidence map›Paper›PMID 32803986›Full record

ArticleThe journal of physical chemistry letters2020

Mixed Phospholipid Vesicles Catalytically Inhibit and Reverse Amyloid Fibril Formation.

Andres F Chaparro Sosa, Sabrina Matos de Oliveira da Silva, Garry P Morgan, Daniel K Schwartz, Joel L Kaar

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mitochondrial membranes modify mutant huntingtin aggregation.Biochimica et biophysica acta. Biomembranes · 2021
    Article
  5. Lipid membranes induce structural conversion from amyloid oligomers to fibrils.Biochemical and biophysical research communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andres F Chaparro SosaDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, United States.ORCID http://orcid.org/0000-0003-4094-6194
Sabrina Matos de Oliveira da SilvaDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, United States.
Garry P MorganDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Daniel K SchwartzDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, United States.ORCID http://orcid.org/0000-0001-5397-7200
Joel L KaarDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, United States.ORCID http://orcid.org/0000-0002-0794-3955
University of Colorado Boulder · US

Funding

Inhibition of Amyloid Formation by Heterogeneous Nanoparticles with Chaperone-like ActivityR21AG062979 · NIA · UNIVERSITY OF COLORADO · PI KAAR, JOEL · 2019 to 2020
$378k
NIA NIH HHS R21 AG062979
6 · The paper itself

Abstract

While many approaches to reduce fibrillation of amyloid-β (Aβ) have been aimed at slowing fibril formation, the degradation of fibrils remains challenging. We provide insight into fibril degradation as well as the inhibition of fiber formation by lipid vesicles composed of 1,2-dioleoyl-

Indexed as

AmyloidCatalysisGlycerolModels, MolecularPhospholipidsPhosphorylcholineProtein AggregatesProtein Conformation, beta-StrandAmyloidGlycerolPhospholipidsPhosphorylcholineProtein Aggregates

Identifiers

PMID32803986
PMCPMC10164471
OpenAlexW3067641665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.