ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review.The Journal of frailty & aging · 2025Pooled it
- Association of Alzheimer's disease biomarkers with malnutrition and altered body composition in cognitively impaired patients: a cross-sectional memory clinic study.Alzheimer's research & therapy · 2026Article
- Weight, body composition and quality of life changes in a Hungarian community-based body weight management program: an observational cohort analysis.Frontiers in public health · 2026Observational
- Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization.GeroScience · 2025Article
- Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank.Neurology · 2024Article
- Comparison of multiple linear regression and machine learning methods in predicting cognitive function in older Chinese type 2 diabetes patients.BMC neurology · 2024Article
- Association of Motoric Cognitive Risk Syndrome with Sarcopenia and Systemic Inflammation in Pre-Frail Older Adults.Brain sciences · 2023Article
- Total and regional fat-to-muscle mass ratio and risks of incident all-cause dementia, Alzheimer's disease, and vascular dementia.Journal of cachexia, sarcopenia and muscle · 2022Article
- Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants.Molecular psychiatry · 2022Article
- Handgrip strength asymmetry is associated with the risk of neurodegenerative disorders among Chinese older adults.Journal of cachexia, sarcopenia and muscle · 2022Article
- A training program for researchers in population neuroimaging: Early experiences.Frontiers in neuroimaging · 2022Review
- Body composition in patients with rheumatoid arthritis: a narrative literature review.Therapeutic advances in musculoskeletal disease · 2021Review
- Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Body composition and plasma total-tau, neurofilament light chain, and amyloid-β: A population-based study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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6 authors.
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Abstract
introductionA body of literature reported associations between late-life general adiposity measures (eg, body mass index) and dementia. Little is known about the association of late-life body composition with dementia risk.
methodsWe determined this association among cognitively normal participants from the Cardiovascular Health Study- Cognition Study. Body composition was assessed by dual-energy x-ray absorptiometry in 1994-1995. Dementia was ascertained at annual follow-up from 1998-1999 to 2013. Associations of body composition with incident dementia were assessed by the Fine-Gray model.
resultAmong 344 participants (mean age 78, 62.2% women), body composition was significantly different between men and women, despite similar body mass indexes (BMIs). Increased dementia risk was significantly associated with lower lean mass in men and marginally with low appendicular lean mass in women. DISCUSSION: Decreased lean mass was an indicator of increased dementia risk in older adults. Studies should test whether preventing lean mass loss in older adults reduces dementia risk.
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