Evidence map›Paper›PMID 32803757›Full record

ArticleThe EMBO journal2020

A hairy tale: SIRT7 safeguards skin stem cells during aging.

Matthew Simon, Stephan Emmrich, Andrei Seluanov, Vera Gorbunova

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew SimonDepartment of Biology, University of Rochester, Rochester, NY, USA.
Stephan EmmrichDepartment of Biology, University of Rochester, Rochester, NY, USA.
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY, USA.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-8979-0333
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
Regulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7M
Regulation of genome stability by SITR6R01AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI SELUANOV, ANDREI · 2014 to 2018
$1.9M
Comparative Analysis of DNA Break Repair in Short- and Long-Lived Rodent SpeciesR01AG031227 · NIA · UNIVERSITY OF ROCHESTER · PI GORBUNOVA, VERA · 2008 to 2012
$1.6M
Comparative analysis of IGF-1 and mTOR signaling in short- and long-lived rodentsR03AG052365 · NIA · UNIVERSITY OF ROCHESTER · PI GORBUNOVA, VERA · 2016 to 2017
$154k
NIA NIH HHS P01 AG047200NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG031227NIA NIH HHS R01 AG046320NIA NIH HHS R03 AG052365NIA NIH HHS R37 AG046320
6 · The paper itself

Abstract

Stem cell regulation during both normal development and aging has become one of the fastest growing topics in biology. Here, new work by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and highlights how SIRT7, a member of the sirtuin family of protein deacylases and mono-ADP ribosylases, protects adult hair follicle stem cells from aging by ensuring their hair cycle progression.

Indexed as

Hair FollicleSirtuinsAgingAnimalsMiceSkin Physiological PhenomenaStem CellsSirt7 protein, mouseSirtuins

Identifiers

PMID32803757
PMCPMC7507574
OpenAlexW3049324996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.