Evidence map›Paper›PMID 32803714›Full record

ArticleScience China. Life sciences2021

Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice.

Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Characterization of theAnimal biotechnology · 2023
    Article
  3. Review
  4. Neuronal cilia in energy homeostasis.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Wenyu Ding *State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Changjiang Zhang *State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Baisong WangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Xin ZhouState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Le SunState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Suijuan ZhongState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Jing LiuState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Junjing ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Xiaoqun WangState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. xiaoqunwang@ibp.ac.cn.
Qian WuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. qianwu@bnu.edu.cn.
Beijing Normal University · CNCenter for Excellence in Brain Science and Intelligence Technology · CNInstitute of Biophysics · CNChinese Institute for Brain Research · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cenpj is a centrosomal protein located at the centrosomes and the base of cilia, it plays essential roles in regulating neurogenesis and cerebral cortex development. Although centrosomal and cilium dysfunction are one of the causes of obesity, insulin resistance, and type 2 diabetes, the role that Cenpj plays in the regulation of body weight remains unclear. Here, we deleted Cenpj by crossing Cenpj

Indexed as

Gene Knockdown TechniquesAnimalsApoptosisCell LineCell ProliferationHypothalamusMiceMicrotubule-Associated ProteinsNeuronsObesity, MorbidPro-OpiomelanocortinReceptor, Melanocortin, Type 4Thyroid Nuclear Factor 1Cenpj protein, mouseMC4R protein, mouseMicrotubule-Associated ProteinsNkx2-1 protein, mousePro-OpiomelanocortinReceptor, Melanocortin, Type 4Thyroid Nuclear Factor 1arcuate nucleusCenpjcentrosomal proteinhypothalamusNkx2.1paraventricular nucleus

Identifiers

PMID32803714
OpenAlexW3049227694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.