Evidence map›Paper›PMID 32803608›Full record

ArticleEnvironmental science and pollution research international2020

Exposure to the herbicide 2,4-dichlorophenoxyacetic acid impairs mitochondrial function, oxidative status, and behavior in adult zebrafish.

Nathana Andressa Thiel, Adrieli Sachett, Sabrina Ester Schneider, Cristiane Garbinato, Laura Decui, Tuany Eichwald, Greicy M M Conterato, Alexandra Latini, Angelo Piato, Anna Maria Siebel

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nathana Andressa ThielLaboratório de Genética e Ecotoxicologia Molecular, Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Servidão Anjo da Guarda, 295-D, Efapi, Chapecó, SC, 89809-900, Brazil.
Adrieli SachettLaboratório de Psicofarmacologia e Comportamento, Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Sarmento Leite, 500, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.
Sabrina Ester SchneiderLaboratório de Genética e Ecotoxicologia Molecular, Curso de Ciências Biológicas, Universidade Comunitária da Região de Chapecó, Servidão Anjo da Guarda, 295-D, Efapi, Chapecó, SC, 89809-900, Brazil.
Cristiane GarbinatoLaboratório de Genética e Ecotoxicologia Molecular, Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Servidão Anjo da Guarda, 295-D, Efapi, Chapecó, SC, 89809-900, Brazil.
Laura DecuiLaboratório de Genética e Ecotoxicologia Molecular, Curso de Ciências Biológicas, Universidade Comunitária da Região de Chapecó, Servidão Anjo da Guarda, 295-D, Efapi, Chapecó, SC, 89809-900, Brazil.
Tuany EichwaldLaboratório de Bioenergética e Estresse Oxidativo, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Florianópolis, SC, 88040-900, Brazil.
Greicy M M ConteratoLaboratório de Fisiologia da Reprodução Animal, Departamento de Agricultura, Biodiversidade e Floresta, Universidade Federal de Santa Catarina, Campus de Curitibanos, Rodovia Ulysses Gaboardi, Curitibanos, SC, 89520-000, Brazil.
Alexandra LatiniLaboratório de Bioenergética e Estresse Oxidativo, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Florianópolis, SC, 88040-900, Brazil.
Angelo PiatoLaboratório de Psicofarmacologia e Comportamento, Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Sarmento Leite, 500, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.
Anna Maria SiebelLaboratório de Genética e Ecotoxicologia Molecular, Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Servidão Anjo da Guarda, 295-D, Efapi, Chapecó, SC, 89809-900, Brazil. anna.siebel@unochapeco.edu.br.ORCID http://orcid.org/0000-0002-7896-1456
Universidade Federal de Santa Catarina · BRUniversidade Federal do Rio Grande do Sul · BRCommunity University of Chapecó Region - Unochapecó · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most commonly used herbicides worldwide. While the effects of 2,4-D in target organisms are well known, its consequences in nontarget organisms are not fully explained. Therefore, the purpose of this study was to investigate the effects of the herbicide on mitochondrial energy metabolism, oxidative status, and exploratory behavior in adult zebrafish. Animal exposure to 2,4-D increased cytochrome c oxidase and catalase activities and reduced SOD/CAT ratio, moreover, increased the total distance traveled and the number of crossings. Finally, animals exposed to 2,4-D spent more time in the upper zone of the tank and traveled a long distance in the upper zone. Overall, our results indicate the 2,4-D can provoke disabling effects in nontarget organisms. The obtained data showed that exposure to 2,4-D at environmentally relevant concentrations alters mitochondrial metabolism and antioxidant status and disturbs the zebrafish innate behavior.

Indexed as

HerbicidesZebrafish2,4-Dichlorophenoxyacetic AcidAnimalsMitochondriaOxidative Stress2,4-Dichlorophenoxyacetic AcidHerbicides2,4-DBehaviorHerbicidesMitochondrial energy metabolismOxidative statusZebrafish

Identifiers

PMID32803608
OpenAlexW3049397826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.