Evidence map›Paper›PMID 32803491›Full record

ReviewCurrent pain and headache reports2020

Neurophysiological Mechanisms Supporting Mindfulness Meditation-Based Pain Relief: an Updated Review.

Alex Jinich-Diamant, Eric Garland, Jennifer Baumgartner, Nailea Gonzalez, Gabriel Riegner, Julia Birenbaum, Laura Case, Fadel Zeidan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pain, mindfulness, and placebo: a systematic review.Frontiers in integrative neuroscience · 2024
    Pooled it
  4. Pooled it
  5. Trial
  6. Mindfulness Meditation Reduces Stress and Hospital Stay in Gastrointestinal Tumor Patients During Perioperative Period.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Trial
  7. Trial
  8. Article
  9. Meditation: Philosophical Foundations and its Role in Managing Common Noncommunicable Diseases.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Article
  10. Review
  11. Mindfulness practice time and quality in veterans with chronic pain.Current psychology (New Brunswick, N.J.) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Pain management in cervical cancer.Frontiers in oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex Jinich-DiamantDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Eric GarlandCollege of Social Work, University of Utah, Salt Lake City, UT, USA.
Jennifer BaumgartnerDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Nailea GonzalezDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Gabriel RiegnerDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Julia BirenbaumDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Laura CaseDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Fadel ZeidanDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA. fzeidan@health.ucsd.edu.

Funding

Brain Mechanisms Supporting Mindfulness Meditation-Based Chronic Pain ReliefR01AT009693 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZEIDAN, FADEL · 2018 to 2023
$2.1M
The role of endogenous opioids in mindfulness-based chronic pain reliefR21AT010352 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZEIDAN, FADEL · 2019 to 2020
$433k
Brain Mechanisms Supporting the Modulation of Pain by Meditation and PlaceboR21AT007247 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI COGHILL, ROBERT C · 2012 to 2013
$400k
Brain Mechanisms Supporting Mindfulness-Based Pain ReliefK99AT008238 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZEIDAN, FADEL · 2014 to 2015
$180k
NCCIH NIH HHS K99/R00-AT008238NCCIH NIH HHS R01-AT009693NCCIH NIH HHS R21-AT007247NCCIH NIH HHS R21-AT010352
6 · The paper itself

Abstract

purpose of reviewThis review examines recent (2016 onwards) neuroscientific findings on the mechanisms supporting mindfulness-associated pain relief. To date, its clear that mindfulness lowers pain by engaging brain processes that are distinct from placebo and vary across meditative training level. Due to rapid developments in the field of contemplative neuroscience, an update review on the neuroimaging studies focused on mindfulness, and pain is merited. RECENT

findingsMindfulness-based therapies produce reliably reductions in a spectrum of chronic pain conditions through psychological, physiological, and neural mechanisms supporting the modulation of evaluation and appraisal of innocuous and noxious sensory events. Neuroimaging and randomized control studies confirm that mindfulness meditation reliably reduces experimentally induced and clinical pain by engaging multiple, unique, non-opioidergic mechanisms that are distinct from placebo and which vary across meditative training level. These promising findings underscore the potential of mindfulness-based approaches to produce long-lasting improvements in pain-related symptomology.

Indexed as

MindfulnessPain ManagementBrainChronic PainHumansMeditationPain MeasurementAnalgesiaMeditationMindfulnessPain

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.