ArticleSkeletal radiology2021
Dual-energy CT collagen density mapping of wrist ligaments reveals tissue remodeling in CPPD patients: first results from a clinical cohort.
Article in Skeletal radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Collagen-sensitive dual-energy-CT as a quantitative tool for tendinopathy assessment: a prospective diagnostic accuracy study.Skeletal radiology · 2026Article
- Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials.Skeletal radiology · 2025Review
- Dual-energy computed tomography collagen density mapping of the temporomandibular disc.BMC medical imaging · 2025Article
- Assessment of thoracic disc degeneration using dual-energy CT-based collagen maps.European radiology experimental · 2024Article
- Updates on the Applications of Spectral Computed Tomography for Musculoskeletal Imaging.Diagnostics (Basel, Switzerland) · 2024Review
- Computed tomography-current status and future directions for arthritis imaging.Therapeutic advances in musculoskeletal disease · 2024Review
- Four-dimensional computed tomography detects dynamic three-dimensional pathologies of the wrist in patients with calcium pyrophosphate deposition disease.Frontiers in medicine · 2023Article
- Dual-Energy Computed Tomography Collagen Density Mapping of the Cranio-Cervical Ligaments-A Retrospective Feasibility Study.Diagnostics (Basel, Switzerland) · 2022Article
- Imaging of Joints and Bones in Autoinflammation.Journal of clinical medicine · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group in order to gain insight into changes of the extracellular matrix in response to crystal deposition. MATERIALS AND
methodsThis retrospective study included 28 patients (18 with CPPD, 10 controls) who underwent DECT of the wrist. Collagen density maps were reconstructed from the DECT datasets and used to measure densities in regions of interest (ROIs) placed in the scapholunate (SL) ligament (dorsal, palmar, proximal), lunotriquetral (LT) ligament, and extensor carpi radialis (ECR) tendon, (n = 260 measurements). The presence of calcifications on standard CT images in these regions was assessed by a blinded reader. Densities were compared with nonparametric tests, and linear regression analysis was performed to investigate the impact of age, sex, and CT- detected calcium deposition on collagen density.
resultsCollagen density in the SL ligament was significantly higher in CPPD patients than in controls (overall mean: 265.4 ± 32.1 HU vs. 196.3 ± 33.8 HU; p < 0.001). In the ECR tendon, collagen densities did not differ significantly (p = 0.672): 161.3 ± 20.1 HU in CPPD vs. 163.6 ± 12.0 HU in controls. Regression analysis showed that diagnosis, but not age or calcification, had a significant impact on collagen density.
conclusionCollagen density of the SL ligament is significantly higher in CPPD patients than in control patients. Further research is needed to understand these changes in the extracellular matrix of ligaments in CPPD.
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